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Myo5b myosin Vb [ Rattus norvegicus (Norway rat) ]

Gene ID: 25132, updated on 27-Nov-2024

Summary

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Official Symbol
Myo5bprovided by RGD
Official Full Name
myosin Vbprovided by RGD
Primary source
RGD:621347
See related
EnsemblRapid:ENSRNOG00000014104 AllianceGenome:RGD:621347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Myr6
Summary
Enables ATP hydrolysis activity; ionotropic glutamate receptor binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to glycine; endosomal transport; and positive regulation of neurogenesis. Located in several cellular components, including dendritic spine; neuronal cell body; and recycling endosome. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic recycling endosome membrane. Human ortholog(s) of this gene implicated in microvillus inclusion disease and progressive familial intrahepatic cholestasis. Orthologous to human MYO5B (myosin VB). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 192.5), Lung (RPKM 58.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myo5b in Genome Data Viewer
Location:
18q12.2
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70313717..70613918)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (68038759..68341568)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70426865..70729985)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482988 Neighboring gene endothelial differentiation-related factor 1, pseudogene 3 Neighboring gene uncharacterized LOC120098281 Neighboring gene uncharacterized LOC120098280 Neighboring gene uncharacterized LOC120098279 Neighboring gene uncharacterized LOC134482961 Neighboring gene uncharacterized LOC120098116 Neighboring gene small Cajal body-specific RNA 18 Neighboring gene small Cajal body-specific RNA 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Provance DW Jr, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14766983, Free PMC Article
  2. Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2. Ji HH, et al. Biosci Rep, 2019 Jan 31. PMID 30545898, Free PMC Article
  3. BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching. Lazo OM, et al. J Neurosci, 2013 Apr 3. PMID 23554492, Free PMC Article
  4. Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. Szperl AM, et al. J Pediatr Gastroenterol Nutr, 2011 Mar. PMID 21206382, Free PMC Article
  5. A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Khandelwal P, et al. Mol Biol Cell, 2013 Apr. PMID 23389633, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Which bridges Myo5b and the membrane-bound Rab11a.
    Title: Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2.
  2. Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development.
    Title: Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development.
  3. Results indicate that Rab11a, Rab8a, and Myo5B function as part of a network to promote stretch-induced exocytosis.
    Title: A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells.
  4. the efficient transport of NPC1L1 to the PM is dependent on the microfilament-associated myosin Vb.Rab11a.Rab11-FIP2 triple complex
    Title: Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.
  5. These results support a model whereby AS160, Rab8A, and myosin Vb are required for insulin-induced GLUT4 translocation in muscle cells, potentially as part of a linear signaling cascade.
    Title: Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.
  6. myosin Vb has a role in in glutamate receptor GluR1 trafficking
    Title: Involvement of myosin Vb in glutamate receptor trafficking.
  7. myosin Vb functions in traffic between peripheral and pericentrosomal compartments
    Title: Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glycine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor transport, endosome to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling via endosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle recycling via endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical cortex IEA
Inferred from Electronic Annotation
more info
  
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
  
located_in apical cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
unconventional myosin-Vb
Names
Myosin of the dilute-myosin-V family
myosin 5B
myosin heavy chain myr 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017083.2 → NP_058779.2  unconventional myosin-Vb

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1M3R4
    Related
    ENSRNOP00000019512.7, ENSRNOT00000019512.8
    Conserved Domains (4) summary
    smart00015
    Location:863 → 883
    IQ; Calmodulin-binding motif
    COG1196
    Location:901 → 1218
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15477
    Location:1472 → 1843
    Myo5b_CBD; Cargo binding domain of myosin 5b
    cd01380
    Location:83 → 751
    MYSc_Myo5; class V myosin, motor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    70313717..70613918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277100.1 → XP_063133170.1  unconventional myosin-Vb isoform X8

    UniProtKB/TrEMBL
    A0A0G2K318
    Related
    ENSRNOP00000105443.1, ENSRNOT00000154755.1

  2. XM_063277099.1 → XP_063133169.1  unconventional myosin-Vb isoform X5

  3. XM_008772085.4 → XP_008770307.1  unconventional myosin-Vb isoform X1

    UniProtKB/TrEMBL
    F1M3R4
    Conserved Domains (10) summary
    smart00015
    Location:871 → 891
    IQ; Calmodulin-binding motif
    smart00242
    Location:72 → 770
    MYSc; Myosin. Large ATPases
    cd15477
    Location:1480 → 1851
    Myo5b_CBD; Cargo binding domain of myosin 5b
    cd01380
    Location:91 → 759
    MYSc_Myo5; class V myosin, motor domain
    pfam04871
    Location:1155 → 1267
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam07956
    Location:910 → 1002
    DUF1690; Protein of Unknown function (DUF1690)
    pfam09311
    Location:919 → 1179
    Rab5-bind; Rabaptin-like protein
    cd16269
    Location:1385 → 1396
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:1340 → 1416
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:979 → 1069
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. XM_017600855.3 → XP_017456344.1  unconventional myosin-Vb isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZST3, A0A8I6ACS1
    Related
    ENSRNOP00000081367.1, ENSRNOT00000094389.2

  5. XM_063277098.1 → XP_063133168.1  unconventional myosin-Vb isoform X4

  6. XM_039096575.2 → XP_038952503.1  unconventional myosin-Vb isoform X10

    UniProtKB/TrEMBL
    A0A8I6G4V2
    Conserved Domains (4) summary
    smart00015
    Location:871 → 891
    IQ; Calmodulin-binding motif
    cd15477
    Location:1434 → 1805
    Myo5b_CBD; Cargo binding domain of myosin 5b
    TIGR02168
    Location:906 → 1244
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01380
    Location:91 → 759
    MYSc_Myo5; class V myosin, motor domain

  7. XM_063277102.1 → XP_063133172.1  unconventional myosin-Vb isoform X11

  8. XM_017600852.3 → XP_017456341.1  unconventional myosin-Vb isoform X2

    UniProtKB/TrEMBL
    F1M3R4

  9. XM_008772086.4 → XP_008770308.1  unconventional myosin-Vb isoform X7

    UniProtKB/TrEMBL
    A0A8I6ACS1
    Conserved Domains (8) summary
    smart00015
    Location:871 → 891
    IQ; Calmodulin-binding motif
    smart00242
    Location:72 → 770
    MYSc; Myosin. Large ATPases
    cd15477
    Location:1453 → 1824
    Myo5b_CBD; Cargo binding domain of myosin 5b
    cd01380
    Location:91 → 759
    MYSc_Myo5; class V myosin, motor domain
    pfam04871
    Location:1154 → 1266
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam07956
    Location:910 → 1002
    DUF1690; Protein of Unknown function (DUF1690)
    pfam14915
    Location:924 → 1216
    CCDC144C; CCDC144C protein coiled-coil region
    cl23720
    Location:979 → 1069
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  10. XM_063277101.1 → XP_063133171.1  unconventional myosin-Vb isoform X9

  11. XM_063277103.1 → XP_063133173.1  unconventional myosin-Vb isoform X12

  12. XM_063277104.1 → XP_063133174.1  unconventional myosin-Vb isoform X13

  13. XM_063277105.1 → XP_063133175.1  unconventional myosin-Vb isoform X13

  14. XM_017600854.3 → XP_017456343.1  unconventional myosin-Vb isoform X3

    UniProtKB/TrEMBL
    F1M3R4
    Related
    ENSRNOP00000069482.3, ENSRNOT00000085318.3

  15. XM_006254908.5 → XP_006254970.1  unconventional myosin-Vb isoform X14

    UniProtKB/TrEMBL
    F1M3R4
    Conserved Domains (7) summary
    smart00015
    Location:625 → 645
    IQ; Calmodulin-binding motif
    smart00242
    Location:1 → 524
    MYSc; Myosin. Large ATPases
    cd15477
    Location:1234 → 1605
    Myo5b_CBD; Cargo binding domain of myosin 5b
    cl22853
    Location:1 → 513
    Motor_domain; Myosin and Kinesin motor domain
    pfam07956
    Location:664 → 756
    DUF1690; Protein of Unknown function (DUF1690)
    pfam09311
    Location:673 → 933
    Rab5-bind; Rabaptin-like protein
    cl23720
    Location:733 → 823
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  16. XM_039096576.2 → XP_038952504.1  unconventional myosin-Vb isoform X15

    UniProtKB/TrEMBL
    A6KRF7, A6KRF8
    Conserved Domains (2) summary
    COG5022
    Location:5 → 376
    COG5022; Myosin heavy chain [General function prediction only]
    cd15477
    Location:761 → 1132
    Myo5b_CBD; Cargo binding domain of myosin 5b
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70569.1 GenPept UniProtKB/Swiss-Prot:P70569

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