Stat5b signal transducer and activator of transcription 5B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25126, updated on 27-Nov-2024

Summary

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Official Symbol: Stat5bprovided by RGD
Official Full Name: signal transducer and activator of transcription 5Bprovided by RGD
Primary source: RGD:3774
See related: EnsemblRapid:ENSRNOG00000019075 AllianceGenome:RGD:3774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Stat5b in Genome Data Viewer

Location:: 10q31

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86205148..86276178, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85704841..85775856, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88686207..88712313, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combinatorial interplay among multiple Stat5b-binding response elements with distinguishable biochemical properties is responsible for highly regulated control of IGF-I gene activity by growth hormone.
Title: Biochemical characterization of diverse Stat5b-binding enhancers that mediate growth hormone-activated insulin-like growth factor-I gene transcription.
STAT5b plays an essential role in growth hormone signaling activation and osteoblast differentiation.
Title: MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs.
Thus the alcohol-induced impairment of STAT nuclear translocation can be explained by increased microtubule acetylation and stability.
Title: Hepatic microtubule acetylation and stability induced by chronic alcohol exposure impair nuclear translocation of STAT3 and STAT5B, but not Smad2/3.
the inhibition of Stat5b expression in chondrocytes prevented the GH promoting effects on NF-kappaB-DNA binding, whereas the inhibition of NF-kappaB p65 expression or activity prevented the GH-dependent activation of IGF-1 and bmp2 expression.
Title: Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2.
GH stimulates recruitment of Stat5b to multiple dispersed regions within the IGFI locus
Title: Dispersed Chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription.
STAT2/5a/5b/6 were confirmed to be significantly modulated during focal cerebral ischaemia.
Title: Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion.
Immuno-blot analysis revealed the highest nuclear level of STAT5b in the fetus and during postnatal development, whereas in the adult it decreased.
Title: Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response.
around the end of pregnancy, prolactin loses the ability to activate STAT5b
Title: Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation.
suppressor of cytokine signaling 2 is a direct signal transducer and activator of transcription 5b target in liver
Title: In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver.
STAT-5B/STAT-3/Hsp27/FGF-2 signaling via its involvement in the regulation of vascular smooth muscle growth growth and motility may play an important role in the pathogenesis of vascular disease.
Title: Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

RH94818 (e-PCR)
- UniSTS:120064

RH142912 (e-PCR)
- UniSTS:232159

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Peyer's patch development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Peyer's patch development	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in activated T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in acute-phase response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in development of secondary female sexual characteristics	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within development of secondary female sexual characteristics	ISO Inferred from Sequence Orthology more info
involved_in development of secondary male sexual characteristics	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within development of secondary male sexual characteristics	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythropoietin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in erythropoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in luteinization	IDA Inferred from Direct Assay more info	PubMed
involved_in luteinization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within luteinization	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in mast cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mast cell migration	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in progesterone metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-15	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to interleukin-15	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-2	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to interleukin-2	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-4	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in taurine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect taurine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 5B

Names: Signal transducer and activator of transcription 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022380.2 → NP_071775.1 signal transducer and activator of transcription 5B

See identical proteins and their annotated locations for NP_071775.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P52632

UniProtKB/TrEMBL

A6HJ61

Related

ENSRNOP00000070284.1, ENSRNOT00000081247.3

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86205148..86276178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085258.1 → XP_038941186.1 signal transducer and activator of transcription 5B isoform X2

UniProtKB/Swiss-Prot

P52632

UniProtKB/TrEMBL

A6HJ61

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
XM_039085260.2 → XP_038941188.1 signal transducer and activator of transcription 5B isoform X3

UniProtKB/Swiss-Prot

P52632

Conserved Domains (4) summary

cd10420
Location:539 → 683

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:105 → 296

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:298 → 455

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cl03749
Location:62 → 90

STAT_int; STAT protein, protein interaction domain
XM_039085256.2 → XP_038941184.1 signal transducer and activator of transcription 5B isoform X1

UniProtKB/Swiss-Prot

P52632

UniProtKB/TrEMBL

A0A0G2JSR4

Related

ENSRNOP00000026354.2, ENSRNOT00000026354.5

Conserved Domains (4) summary

cd10420
Location:582 → 726

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:148 → 339

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:341 → 498

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:65 → 133

STAT_int; STAT protein, protein interaction domain
XM_039085259.2 → XP_038941187.1 signal transducer and activator of transcription 5B isoform X2

UniProtKB/Swiss-Prot

P52632

UniProtKB/TrEMBL

A6HJ61

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
XM_039085257.2 → XP_038941185.1 signal transducer and activator of transcription 5B isoform X2

UniProtKB/Swiss-Prot

P52632

UniProtKB/TrEMBL

A6HJ61

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain