Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd11b2provided by RGD
Official Full Name: hydroxysteroid 11-beta dehydrogenase 2provided by RGD
Primary source: RGD:2835
See related: EnsemblRapid:ENSRNOG00000017084 AllianceGenome:RGD:2835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to insulin. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Used to study hypertension. Biomarker of fetal alcohol spectrum disorder; hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 337.0), Adrenal (RPKM 128.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50307569..50312812)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33397656..33402899)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37476083..37481326)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contribution of placental 11beta-HSD2 to the pathogenesis of preeclampsia.
Title: Contribution of placental 11β-HSD2 to the pathogenesis of preeclampsia.
Rac1 GTPase regulates 11beta-HSD2 expression, mineralocorticoid receptor activation, and mineralocorticoid receptor-mediated pro-fibrotic signaling.
Title: Rac1 GTPase regulates 11β hydroxysteroid dehydrogenase type 2 and fibrotic remodeling.
zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas.
Title: Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2.
Specific 11beta-HSD2 immunoreactivity was found in the cytoplasm of the Magnocellular Neurosecretory Cells in both the Supraoptic and Paraventricular nuclei.
Title: Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei.
Maternal exposure to lipopolysaccharide at later gestational ages reduced placental expression
Title: LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation.
11beta-HSD2 and it's signaling factors play roles in pathogenesis of persistent pulmonary hypertension in neonatal rats.
Title: [Roles of type II 11β-hydroxysteroid dehydrogenase and its signaling factors in pathogenesis of persistent pulmonary hypertension in neonatal rats].
Data indicate that miRNA-dependent mechanisms seem to modulate 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) dosage in health and disease states.
Title: Regulation of 11β-hydroxysteroid dehydrogenase type 2 by microRNA.
Both 11beta-HSD1 and 11beta-HSD2 are downregulated after uninephrectomy in rats, a constellation considered to induce hypertension.
Title: Uninephrectomy reduces 11β-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats.
demonstrated expression of mRNA for 11beta-HSD-1 and 11beta-HSD-2 and protein for 11beta-HSD-1 in rat and human pancreatic islets and insulinoma cells
Title: Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase.
Mean methylation of the Hsd11b2 promoter in the Mg-deficient offspring (33.2%) was higher than in controls (10.4%).
Title: Magnesium deficiency in pregnant rats alters methylation of specific cytosines in the hepatic hydroxysteroid dehydrogenase-2 promoter of the offspring.

Submit: New GeneRIF Correction See all GeneRIFs (42)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cortisol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in glucocorticoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood volume by renal aldosterone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 11-beta-hydroxysteroid dehydrogenase type 2

Names: 11-DH2; 11-beta-HSD2; Hydroxysteroid dehydrogenase, 11 beta type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2

NP_058777.1

EC 1.1.1.146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017081.2 → NP_058777.1 11-beta-hydroxysteroid dehydrogenase type 2

See identical proteins and their annotated locations for NP_058777.1

Status: PROVISIONAL

Source sequence(s)

U22424

UniProtKB/Swiss-Prot

P50233

UniProtKB/TrEMBL

A6IYQ2

Related

ENSRNOP00000023130.1, ENSRNOT00000023130.5

Conserved Domains (1) summary

cd09805
Location:83 → 363

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs