Pld2 phospholipase D2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pld2provided by RGD
Official Full Name: phospholipase D2provided by RGD
Primary source: RGD:3350
See related: EnsemblRapid:ENSRNOG00000019604 AllianceGenome:RGD:3350
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pldc
Summary: Enables phospholipase D activity and protein kinase C binding activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of vesicle-mediated transport; and response to hydrogen peroxide. Located in caveola; lamellipodium; and sarcolemma. Biomarker of congestive heart failure and visual epilepsy. Orthologous to human PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 64.5), Lung (RPKM 60.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55754957..55772819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55256326..55274192)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57161921..57181148)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phospholipase D2 targeted by miR-5132-5p alleviates cerulein-induced acute pancreatitis via the Nrf2/NFkappaB pathway.
Title: Phospholipase D2 targeted by miR-5132-5p alleviates cerulein-induced acute pancreatitis via the Nrf2/NFκB pathway.
Increased expression of both Pld1 and Pld2 occurs simultaneously with the appearance of vascular calcification in chronic kidney disease.
Title: Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.
PLD2 toxicity is due to its lipase activity. Overexpression of a catalytically inactive mutant (K758R) of PLD2 prevents the loss of dopaminergic neurons in the substantia nigra pars compacta and does not show signs of toxicity after 10weeks of overexpression. Mutant K758R does not affect dopamine levels in the striatum.
Title: The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.
Phosphatidic acid produced by PLD2 plays an important role in regulating cell morphology in mast cells.
Title: Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.
new insights in the intricate way PLD and mTOR cooperate to control myogenesis
Title: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.
A high level of cell invasiveness of cancer cells can be explained for the first time by combined high JAK3/PLD2 phosphorylation and activity involving PLD2's Y415 residue, which might constitute a novel target to inhibit cancer cell invasion.
Title: Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).
Data demonstrate that alpha-syn is an inhibitor of PLD2 in vivo.
Title: α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.
Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
Title: Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
The level of PLD2 in both the cerebrum and hindbrain was minimal compared to that of PLD1.
Title: Developmental levels of phospholipase D isozymes in the brain of developing rats.
ARF6 protein regulates mu-opioid receptor trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance.
Title: ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pld2 (e-PCR), detects polymorphism
- UniSTS:507159

D10Wox42 (e-PCR)
- UniSTS:518690

D10Wox41 (e-PCR)
- UniSTS:518714

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase D2

Names: PLD 2; PLD1C; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; rPLD2

NP_150641.2

EC 3.1.4.4

XP_038941178.1

EC 3.1.4.4

XP_038941180.1

EC 3.1.4.4

XP_063124524.1

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033299.2 → NP_150641.2 phospholipase D2

See identical proteins and their annotated locations for NP_150641.2

Status: PROVISIONAL

Source sequence(s)

D88672

UniProtKB/Swiss-Prot

O08768, P70498

UniProtKB/TrEMBL

A6HG64

Related

ENSRNOP00000053831.5, ENSRNOT00000056998.6

Conserved Domains (4) summary

cd07297
Location:62 → 192

PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2

PLN02866
Location:67 → 918

PLN02866; phospholipase D

cd01254
Location:180 → 309

PH_PLD; Phospholipase D pleckstrin homology (PH) domain

cl15239
Location:614 → 795

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55754957..55772819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085252.2 → XP_038941180.1 phospholipase D2 isoform X2

Conserved Domains (1) summary

PLN02866
Location:67 → 746

PLN02866; phospholipase D
XM_039085250.2 → XP_038941178.1 phospholipase D2 isoform X1

UniProtKB/Swiss-Prot

O08768, P70498

Conserved Domains (1) summary

PLN02866
Location:67 → 957

PLN02866; phospholipase D
XM_063268454.1 → XP_063124524.1 phospholipase D2 isoform X3