Prss1 serine protease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss1provided by RGD
Official Full Name: serine protease 1provided by RGD
Primary source: RGD:3417
See related: EnsemblRapid:ENSRNOG00000063605 AllianceGenome:RGD:3417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Try1; PTRYI; RATPTRYI
Summary: Predicted to enable serine-type endopeptidase activity. Involved in several processes, including response to acetaldehyde; response to caffeine; and response to nicotine. Located in extracellular space. Biomarker of cystic fibrosis; pancreatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS1 (serine protease 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 12245.4) and Liver (RPKM 3676.1) See more
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Genomic context

Location:: 4q23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (71331249..71334452)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (70364589..70367792)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (70776046..70779249)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation.
Title: Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation.
These results indicate that mucin plays an important role in the preservation of the mucosal barrier and that ischemia but not digestive enzymes disturbs mucin integrity, while digestive enzymes actively mediate epithelial cell disruption.
Title: Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine.
ectopic anionic trypsin I in rat lungs induced by virus infection may trigger virus spread in rat lungs
Title: Identification of ectopic anionic trypsin I in rat lungs potentiating pneumotropic virus infectivity and increased enzyme level after virus infection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d4arb8 (e-PCR)
- UniSTS:121914

d4mgh32 (e-PCR)
- UniSTS:121923

D4Hri2 (e-PCR)
- UniSTS:239737

D4Wox24 (e-PCR)
- UniSTS:117979

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to acetaldehyde	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nicotine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine protease 1

Names: anionic trypsin I; anionic trypsin-1; beta-trypsin; cationic trypsinogen; pancreatic trypsin 1; pretrypsinogen I; protease, serine 1; protease, serine, 1 (trypsin 1); protease, serine, 2; trypsin I; trypsin-1

NP_036767.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012635.1 → NP_036767.1 serine protease 1 precursor

See identical proteins and their annotated locations for NP_036767.1

Status: PROVISIONAL

Source sequence(s)

V01273

UniProtKB/Swiss-Prot

P00762

UniProtKB/TrEMBL

A6IF31

Related

ENSRNOP00000086707.1, ENSRNOT00000108811.2

Conserved Domains (2) summary

smart00020
Location:23 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...