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Cby1 chibby 1, beta catenin antagonist [ Rattus norvegicus (Norway rat) ]

Gene ID: 246768, updated on 27-Nov-2024

Summary

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Official Symbol
Cby1provided by RGD
Official Full Name
chibby 1, beta catenin antagonistprovided by RGD
Primary source
RGD:708481
See related
EnsemblRapid:ENSRNOG00000090732 AllianceGenome:RGD:708481
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pgea1
Summary
Predicted to enable beta-catenin binding activity and protein homodimerization activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of Wnt signaling pathway; and protein homotetramerization. Predicted to act upstream of or within cilium assembly; floor plate development; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriole; ciliary basal body; and trans-Golgi network. Predicted to be active in nucleus. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 143.2), Brain (RPKM 116.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cby1 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113097220..113103831)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111216835..111223305)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120891930..120898318)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A Neighboring gene uncharacterized LOC134479938 Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway. Mokhtarzada S, et al. Biochemistry, 2011 Feb 8. PMID 21182262, Free PMC Article
  2. Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Singh AM, et al. Circulation, 2007 Feb 6. PMID 17261658, Free PMC Article
  3. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. Hidaka S, et al. J Biol Chem, 2004 Aug 13. PMID 15194699
  4. A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. Steere N, et al. PLoS One, 2012. PMID 22911743, Free PMC Article
  5. Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Li FQ, et al. Mol Cell Biol, 2007 Jun. PMID 17403895, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within floor plate development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein chibby homolog 1
Names
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
PKD2 interactor, golgi and endoplasmic reticulum associated 1
chibby family member 1, beta catenin antagonist
chibby homolog 1
cytosolic leucine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145676.2 → NP_663709.1  protein chibby homolog 1

    See identical proteins and their annotated locations for NP_663709.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Conserved Domains (1) summary
    pfam14645
    Location:1 → 114
    Chibby; Chibby family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    113097220..113103831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078427.2 → XP_038934355.1  protein chibby homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Conserved Domains (1) summary
    pfam14645
    Location:1 → 114
    Chibby; Chibby family

  2. XM_006241967.5 → XP_006242029.1  protein chibby homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006242029.1

    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Conserved Domains (1) summary
    pfam14645
    Location:1 → 114
    Chibby; Chibby family

  3. XM_063262997.1 → XP_063119067.1  protein chibby homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Related
    ENSRNOP00000105864.1, ENSRNOT00000145467.1

  4. XM_039078426.2 → XP_038934354.1  protein chibby homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Conserved Domains (1) summary
    pfam14645
    Location:1 → 114
    Chibby; Chibby family

  5. XM_039078425.2 → XP_038934353.1  protein chibby homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K4I6
    UniProtKB/TrEMBL
    A6HST0
    Conserved Domains (1) summary
    pfam14645
    Location:1 → 114
    Chibby; Chibby family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4I6.1 GenPept UniProtKB/Swiss-Prot:Q8K4I6

Gene LinkOut

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