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PIG-X Phosphatidylinositol glycan anchor biosynthesis class X [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246580, updated on 4-Jan-2025

Summary

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Official Symbol
PIG-Xprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Xprovided by FlyBase
Primary source
FLYBASE:FBgn0050381
Locus tag
Dmel_CG30381
See related
AllianceGenome:FB:FBgn0050381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30381; Dmel\CG30381
Summary
Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PIGX (phosphatidylinositol glycan anchor biosynthesis class X). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See PIG-X in Genome Data Viewer
Location:
43F2-43F2; 2-57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7929658..7931016, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3817163..3818521, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cullin 1 Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene ribonuclease H1 Neighboring gene drosha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
  2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  3. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article
  4. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class X
Names
CG30381-PB
CG30381-PC
PIG-X-PB
PIG-X-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7929658..7931016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103751.2 → NP_001097221.1  phosphatidylinositol glycan anchor biosynthesis class X, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY62, F3YDB9
    Conserved Domains (1) summary
    pfam08320
    Location:3 → 212
    PIG-X; PIG-X / PBN1

  2. NM_001299243.1 → NP_001286172.1  phosphatidylinositol glycan anchor biosynthesis class X, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LES9, F3YDB9
    Conserved Domains (1) summary
    pfam08320
    Location:3 → 218
    PIG-X; PIG-X / PBN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LES9 A0A0B4LES9
A8DY62 A8DY62

Gene LinkOut

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