Vha100-3 Vacuolar H[+] ATPase 100kD subunit 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha100-3provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 100kD subunit 3provided by FlyBase
Primary source: FLYBASE:FBgn0028669
Locus tag: Dmel_CG30329
See related: AllianceGenome:FB:FBgn0028669
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:AT03238; CG30329; Dmel\CG30329; vha100-3
Summary: Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A2 (ATPase H+ transporting V0 subunit a2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18908961..18911895, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14796466..14799400, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATPase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain