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Cht12 Chitinase 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246535, updated on 4-Jan-2025

Summary

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Official Symbol
Cht12provided by FlyBase
Official Full Name
Chitinase 12provided by FlyBase
Primary source
FLYBASE:FBgn0050293
Locus tag
Dmel_CG30293
See related
AllianceGenome:FB:FBgn0050293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT18578; CG30293; Cht; cht12; DmCht12; Dmel\CG30293; NEST:bs09g08; NEST:bs28h08; NEST:bs33a06
Summary
Predicted to enable chitinase activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and regulation of tube architecture, open tracheal system. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cht12 in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21063178..21064986, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16950683..16952491, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene capping protein alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. Nelson CS, et al. BMC Genomics, 2016 Nov 4. PMID 27809764, Free PMC Article
  2. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
  3. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175
  4. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article
  5. Chitinases and Imaginal disc growth factors organize the extracellular matrix formation at barrier tissues in insects. Pesch YY, et al. Sci Rep, 2016 Feb 3. PMID 26838602, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables chitinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube architecture, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitinase 12
Names
CG30293-PA
Cht12-PA
NP_726022.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21063178..21064986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166420.2 → NP_726022.1  chitinase 12 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLW8, Q8T443
    Related
    FBpp0071473
    Conserved Domains (3) summary
    smart00494
    Location:394 → 438
    ChtBD2; Chitin-binding domain type 2
    pfam00704
    Location:47 → 355
    Glyco_hydro_18; Glycosyl hydrolases family 18
    cl10447
    Location:25 → 375
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MLW8 Q8MLW8
Q8T443 Q8T443

Gene LinkOut

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