HSPC300 Haematopoietic stem/progenitor cell protein 300 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HSPC300provided by FlyBase
Official Full Name: Haematopoietic stem/progenitor cell protein 300provided by FlyBase
Primary source: FLYBASE:FBgn0061198
Locus tag: Dmel_CG30173
See related: AllianceGenome:FB:FBgn0061198
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Brk1; CG30173; dHSPC; dHSPC300; Dmel\CG30173; SIP1
Summary: Involved in several processes, including central nervous system morphogenesis; positive regulation of plasma membrane bounded cell projection assembly; and regulation of synaptic assembly at neuromuscular junction. Part of SCAR complex. Is expressed in larval central nervous system; larval longitudinal connective; organism; ovary; and symmetrical commissure. Orthologous to human BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24027717..24028789, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19915240..19916312, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCAR complex	IEA Inferred from Electronic Annotation more info

Names: CG30173-PA; CG30173-PB; HSPC300-PA; HSPC300-PB; syntaxin interacting protein 1

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The following sections contain reference sequences that belong to a specific genome build. Explain