Slc45a1 solute carrier family 45, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc45a1provided by RGD
Official Full Name: solute carrier family 45, member 1provided by RGD
Primary source: RGD:708502
See related: EnsemblRapid:ENSRNOG00000018229 AllianceGenome:RGD:708502
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnb5; Pasta; Past-A
Summary: Enables D-glucose:proton symporter activity and galactose:proton symporter activity. Involved in D-glucose transmembrane transport and galactose transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC45A1 (solute carrier family 45 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 72.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (166388115..166412183, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (161105137..161129375, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (167672134..167696331, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI548909 (e-PCR)
- UniSTS:243720

BE095521 (e-PCR)
- UniSTS:243469

SHGC-74183 (e-PCR)
- UniSTS:486

BI276205 (e-PCR)
- UniSTS:249838

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose:proton symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables D-glucose:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables galactose:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sucrose:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in galactose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sucrose transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proton-associated sugar transporter A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144747.3 → NP_653348.3 proton-associated sugar transporter A

See identical proteins and their annotated locations for NP_653348.3

Status: VALIDATED

Source sequence(s)

BC093599

UniProtKB/TrEMBL

A0A0G2QC36, A6IUD8, F1LNK7, Q566E3

Related

ENSRNOP00000024581.6, ENSRNOT00000024581.9

Conserved Domains (1) summary

cd17313
Location:88 → 726

MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

166388115..166412183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287159.1 → XP_063143229.1 proton-associated sugar transporter A isoform X1
XM_039109270.2 → XP_038965198.1 proton-associated sugar transporter A isoform X1

Conserved Domains (1) summary

cl28910
Location:3 → 546

MFS; Major Facilitator Superfamily