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Bpifa1 BPI fold containing family A, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246238, updated on 27-Nov-2024

Summary

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Official Symbol
Bpifa1provided by RGD
Official Full Name
BPI fold containing family A, member 1provided by RGD
Primary source
RGD:619818
See related
EnsemblRapid:ENSRNOG00000013859 AllianceGenome:RGD:619818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plunc
Summary
Predicted to enable lipid binding activity. Predicted to be involved in several processes, including defense response to symbiont; multicellular organismal-level water homeostasis; and negative regulation of single-species biofilm formation in or on host organism. Located in microvillus. Orthologous to human BPIFA1 (BPI fold containing family A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1629.0) See more
Orthologs
human mouse all
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Genomic context

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See Bpifa1 in Genome Data Viewer
Location:
3q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163087965..163093708)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142627810..142633553)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149624867..149630610)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene BPI fold containing family A, member 3 Neighboring gene uncharacterized LOC134486304 Neighboring gene BPI fold containing family A, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. Lindahl M, et al. Electrophoresis, 2001 May. PMID 11425234
  2. SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Liu Y, et al. Am J Pathol, 2013 May. PMID 23499554, Free PMC Article
  3. Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. Sung YK, et al. J Biol Chem, 2002 Apr 12. PMID 11821380
  4. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Hobbs CA, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Dec. PMID 24124190, Free PMC Article
  5. Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Fornander L, et al. Proteomics Clin Appl, 2011 Oct. PMID 21805676

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial humoral response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response in nasopharyngeal-associated lymphoid tissue IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response in nasopharyngeal-associated lymphoid tissue ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organismal-level water homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organismal-level water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of single-species biofilm formation in or on host organism IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of single-species biofilm formation in or on host organism ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single-species biofilm formation in or on host organism ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in surfactant homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in surfactant homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BPI fold-containing family A member 1
Names
ES cell-related protein
palate lung and nasal epithelium clone protein
palate, lung and nasal epithelium associated
palate, lung, and nasal epithelium carcinoma associated protein
palate, lung, and nasal epithelium expressed transcript
protein Plunc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172031.2 → NP_742028.1  BPI fold-containing family A member 1 precursor

    See identical proteins and their annotated locations for NP_742028.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8K4I4
    UniProtKB/TrEMBL
    A6KHX6
    Related
    ENSRNOP00000018581.3, ENSRNOT00000018581.6
    Conserved Domains (1) summary
    pfam01273
    Location:85 → 248
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    163087965..163093708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104251.2 → XP_038960179.1  BPI fold-containing family A member 1 isoform X1

    Related
    ENSRNOP00000102338.1, ENSRNOT00000138935.1
    Conserved Domains (1) summary
    pfam01273
    Location:109 → 272
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4I4.1 GenPept UniProtKB/Swiss-Prot:Q8K4I4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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