Lrit1 leucine-rich repeat, Ig-like and transmembrane domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrit1provided by RGD
Official Full Name: leucine-rich repeat, Ig-like and transmembrane domains 1provided by RGD
Primary source: RGD:628607
See related: EnsemblRapid:ENSRNOG00000012790 AllianceGenome:RGD:628607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pal; Lrrc21
Summary: Predicted to be involved in visual perception. Located in endoplasmic reticulum membrane. Orthologous to human LRIT1 (leucine rich repeat, Ig-like and transmembrane domains 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (12842339..12850266)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (12822076..12830003)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (14306804..14314731)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1

Names: leucine rich repeat containing 21; leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; leucine-rich repeat-containing protein 21; photoreceptor-associated LRR superfamily protein; putative type I transmembrane protein; retina specific glycoprotein; retina-specific protein PAL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139331.2 → NP_647547.2 leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_647547.2

Status: VALIDATED

Source sequence(s)

AB028461

UniProtKB/Swiss-Prot

Q9JMH2

UniProtKB/TrEMBL

A0A0H2UHK6, A6K9I9

Related

ENSRNOP00000017773.3, ENSRNOT00000017773.4

Conserved Domains (8) summary

smart00013
Location:23 → 61

LRRNT; Leucine rich repeat N-terminal domain

smart00060
Location:431 → 501

FN3; Fibronectin type 3 domain

smart00410
Location:267 → 345

IG_like; Immunoglobulin like

sd00031
Location:64 → 84

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:131 → 172

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:63 → 143

LRR_8; Leucine rich repeat

cl11960
Location:257 → 345

Ig; Immunoglobulin domain

cl15307
Location:201 → 240

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain