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Rhbdl3 rhomboid like 3 [ Mus musculus (house mouse) ]

Gene ID: 246104, updated on 27-Nov-2024

Summary

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Official Symbol
Rhbdl3provided by MGI
Official Full Name
rhomboid like 3provided by MGI
Primary source
MGI:MGI:2179276
See related
Ensembl:ENSMUSG00000017692 AllianceGenome:MGI:2179276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vrho; Rhbdl4; Rhomr1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; reproductive system; sensory organ; and thymus. Orthologous to human RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Rhbdl3 in Genome Data Viewer
Location:
11 B5; 11 47.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80191296..80246812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80300471..80355986)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7025 Neighboring gene ring finger protein 135 Neighboring gene ras homolog family member T1 Neighboring gene STARR-seq mESC enhancer starr_30145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:80116169-80116470 Neighboring gene RIKEN cDNA 5730455P16 gene Neighboring gene STARR-positive B cell enhancer ABC_E7026 Neighboring gene STARR-seq mESC enhancer starr_30146 Neighboring gene zinc finger protein 207

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα. Wunderle L, et al. Sci Rep, 2016 Jun 6. PMID 27264103, Free PMC Article
  2. Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid. Jászai J, et al. Mech Dev, 2002 Apr. PMID 11900977
  3. RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Knopf JD, et al. Nat Commun, 2024 Mar 7. PMID 38453906, Free PMC Article
  4. Unified rhombic lip origins of group 3 and group 4 medulloblastoma. Smith KS, et al. Nature, 2022 Sep. PMID 36131015, Free PMC Article
  5. Characterization of the proneural gene regulatory network during mouse telencephalon development. Gohlke JM, et al. BMC Biol, 2008 Mar 31. PMID 18377642, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.
    Title: RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.
  2. Here the authors show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles.
    Title: Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.
  3. Cloning and expression of Ventrhoid
    Title: Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rhomboid-related protein 3
Names
rhomboid protease 3
rhomboid related gene 1
rhomboid, veinlet-like 3
rhomboid, veinlet-like 4
ventrhoid transmembrane protein
NP_631974.1
XP_006533389.1
XP_006533390.1
XP_006533391.1
XP_006533392.1
XP_006533393.1
XP_006533394.1
XP_011247323.1
XP_030101866.1
XP_036012597.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139228.3 → NP_631974.1  rhomboid-related protein 3

    See identical proteins and their annotated locations for NP_631974.1

    Status: VALIDATED

    Source sequence(s)
    AL591146, AL591426, BC054784
    Consensus CDS
    CCDS25131.1
    UniProtKB/Swiss-Prot
    P58873
    Related
    ENSMUSP00000017836.8, ENSMUST00000017836.8
    Conserved Domains (2) summary
    pfam01694
    Location:207 → 359
    Rhomboid; Rhomboid family
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80191296..80246812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533326.5 → XP_006533389.1  rhomboid-related protein 3 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair
    cl21536
    Location:207 → 260
    Rhomboid; Rhomboid family

  2. XM_006533331.3 → XP_006533394.1  rhomboid-related protein 3 isoform X6

    Conserved Domains (1) summary
    cl21536
    Location:154 → 207
    Rhomboid; Rhomboid family

  3. XM_006533327.4 → XP_006533390.1  rhomboid-related protein 3 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair
    cl21536
    Location:207 → 260
    Rhomboid; Rhomboid family

  4. XM_006533328.3 → XP_006533391.1  rhomboid-related protein 3 isoform X3

    Conserved Domains (2) summary
    PTZ00184
    Location:38 → 94
    PTZ00184; calmodulin; Provisional
    cl21536
    Location:199 → 252
    Rhomboid; Rhomboid family

  5. XM_011249021.3 → XP_011247323.1  rhomboid-related protein 3 isoform X7

    Conserved Domains (1) summary
    cl21536
    Location:146 → 199
    Rhomboid; Rhomboid family

  6. XM_006533329.3 → XP_006533392.1  rhomboid-related protein 3 isoform X4

    Conserved Domains (2) summary
    pfam01694
    Location:207 → 358
    Rhomboid; Rhomboid family
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair

  7. XM_006533330.3 → XP_006533393.1  rhomboid-related protein 3 isoform X5

    Conserved Domains (2) summary
    PTZ00184
    Location:38 → 94
    PTZ00184; calmodulin; Provisional
    pfam01694
    Location:199 → 351
    Rhomboid; Rhomboid family

  8. XM_036156704.1 → XP_036012597.1  rhomboid-related protein 3 isoform X8

    Conserved Domains (1) summary
    pfam01694
    Location:144 → 298
    Rhomboid; Rhomboid family

  9. XM_030246006.2 → XP_030101866.1  rhomboid-related protein 3 isoform X9

    Conserved Domains (1) summary
    cl21536
    Location:109 → 162
    Rhomboid; Rhomboid family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58873.1 GenPept UniProtKB/Swiss-Prot:P58873

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