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Odc1 ornithine decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24609, updated on 27-Nov-2024

Summary

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Official Symbol
Odc1provided by RGD
Official Full Name
ornithine decarboxylase 1provided by RGD
Primary source
RGD:3227
See related
EnsemblRapid:ENSRNOG00000005424 AllianceGenome:RGD:3227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Odc
Summary
Enables ornithine decarboxylase activity. Involved in putrescine biosynthetic process. Located in perinuclear region of cytoplasm. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 810.1), Thymus (RPKM 444.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Odc1 in Genome Data Viewer
Location:
6q16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46058439..46065148)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40329831..40336444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42852529..42859142)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene craniofacial development protein 1 like 1 Neighboring gene proteasome activator subunit 3, pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 80B Neighboring gene uncharacterized LOC134479118 Neighboring gene uncharacterized LOC134479347

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats. Hayashi T, et al. Hypertens Res, 2002 Sep. PMID 12452334
  2. Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region. Manzella JM, et al. J Biol Chem, 1990 Jul 15. PMID 2365701
  3. Immunocytochemical detection of ornithine decarboxylase. Schipper RG, et al. J Histochem Cytochem, 1999 Nov. PMID 10544213
  4. Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene. Wen L, et al. J Biol Chem, 1989 May 25. PMID 2722815
  5. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors? Deng A, et al. Diabetes, 2003 May. PMID 12716758

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicated that overexpression of ODC gene promotes the proliferation while suppressing apoptosis of fibroblast-like synoviocytes in rats with rheumatoid arthritis.
    Title: Effects of lentivirus-mediated ornithine decarboxylase gene on the proliferation and apoptosis of fibroblast-like synoviocytes in rats with arthritis.
  2. These results suggest that IPC upregulates the Ornithine decarboxylase/polyamine system and mediates preconditioning cardioprotection.
    Title: Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores.
  3. The modulation of ODC activity by AMPK represents a mechanism that may contribute to control cell growth processes.
    Title: Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts.
  4. effect of deep hypothermia on the ODC activity
    Title: The effect of hypothermia on the ornithine decarboxylase activity in tissues of rats.
  5. Overexpression of ornithine decarboxylase increases myogenic potential of rat myoblasts.
    Title: Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts.
  6. Results show that transglutaminase-catalyzed polyamination of rhoA regulates its activity, and that ornithine decarboxylase influences the intracellular distribution of rhoA.
    Title: Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination.
  7. The tumor-like proliferation of synoviocytes from AA rat joint might be related to the increased mRNAs of C-myc and ODC genes.
    Title: [The study on the relationship between the tumor-like proliferation of synoviocytes and the expression of c-myc and ODC genes in adjuvant arthritis rats].
  8. ODC is necessary for hyperresponsiveness of the proximal tubule to dietary salt and for the paradoxical effect of dietary salt on GFR in early diabetes
    Title: Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.
  9. The aim of this study was to investigate the role of TG2, ODC, and their products in regenerating rat liver after partial hepatectomy by using retinoic acid.
    Title: Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration.
  10. Corticosterone decreases ODC mRNA and enzyme protein both in the intact liver and the regenerating liver.
    Title: Regulatory effects of corticosterone on ornithine decarboxylase activity during liver regeneration in rats.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ornithine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in polyamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine biosynthetic process from ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine biosynthetic process from ornithine IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine biosynthetic process from ornithine ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine biosynthetic process from ornithine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ornithine decarboxylase
Names
Ornitine decarboxylase
NP_001289012.1
NP_036747.1
XP_006239969.1
XP_006239970.1
XP_017449519.1
XP_063117614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302083.1 → NP_001289012.1  ornithine decarboxylase

    See identical proteins and their annotated locations for NP_001289012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has two alternate splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    DV728774, FQ151473, J04791, M16982
    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9
    Conserved Domains (2) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:40 → 408
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

  2. NM_012615.3 → NP_036747.1  ornithine decarboxylase

    See identical proteins and their annotated locations for NP_036747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078882, DV728774, FQ151473, M16982
    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9
    Conserved Domains (2) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:40 → 408
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    46058439..46065148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594030.2 → XP_017449519.1  ornithine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9
    Related
    ENSRNOP00000007259.2, ENSRNOT00000007259.6
    Conserved Domains (2) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:40 → 408
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

  2. XM_006239907.5 → XP_006239969.1  ornithine decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006239969.1

    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9
    Conserved Domains (2) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:40 → 408
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

  3. XM_063261544.1 → XP_063117614.1  ornithine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9

  4. XM_006239908.5 → XP_006239970.1  ornithine decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006239970.1

    UniProtKB/Swiss-Prot
    P09057
    UniProtKB/TrEMBL
    A6HAU9
    Conserved Domains (2) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:40 → 408
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09057.1 GenPept UniProtKB/Swiss-Prot:P09057

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