pcf-11 CID domain-containing protein;Polyadenylation and cleavage factor homolog 11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pcf-11
Official Full Name: CID domain-containing protein;Polyadenylation and cleavage factor homolog 11
Primary source: WormBase:WBGene00020092
Locus tag: CELE_R144.2
See related: AllianceGenome:WB:WBGene00020092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II complex binding activity and mRNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be located in membrane. Predicted to be part of mRNA cleavage factor complex. Predicted to be active in cytoplasm. Orthologous to human PCF11 (PCF11 cleavage and polyadenylation factor subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pcf-11 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (5024914..5029647)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R144.2 (e-PCR)
- UniSTS:306350

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II complex binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase II transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in termination of RNA polymerase II transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA cleavage factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CID domain-containing protein;Polyadenylation and cleavage factor homolog 11

NP_001367577.1

Confirmed by transcript evidence

NP_498068.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5024914..5029647

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379694.3 → NP_001367577.1 CID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IFZ4

Conserved Domains (1) summary

cd16982
Location:8 → 138

CID_Pcf11; CID (CTD-Interacting Domain) of Pcf11
NM_065667.7 → NP_498068.1 Polyadenylation and cleavage factor homolog 11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498068.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09345

Conserved Domains (1) summary

cd03562
Location:8 → 121

CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...