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Coro6 coronin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245982, updated on 2-Nov-2024

Summary

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Official Symbol
Coro6provided by RGD
Official Full Name
coronin 6provided by RGD
Primary source
RGD:708560
See related
EnsemblRapid:ENSRNOG00000014496 AllianceGenome:RGD:708560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. Orthologous to human CORO6 (coronin 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 190.7), Heart (RPKM 139.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coro6 in Genome Data Viewer
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62808172..62817788)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62311552..62319659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62691952..62700658, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene slingshot protein phosphatase 2 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene ankyrin repeat domain 13B Neighboring gene GIT ArfGAP 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. Chen Y, et al. J Neurosci, 2014 Feb 12. PMID 24523531, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction
    Title: Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112600

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coronin-6
Names
clipin E
coronin relative protein
coronin, actin binding protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139115.2 → NP_620815.2  coronin-6

    See identical proteins and their annotated locations for NP_620815.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098656
    UniProtKB/Swiss-Prot
    Q4G087, Q920J3
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 466
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:344 → 386
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    62808172..62817788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246886.5 → XP_006246948.1  coronin-6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWB1
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 466
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:344 → 386
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006246888.5 → XP_006246950.1  coronin-6 isoform X4

    See identical proteins and their annotated locations for XP_006246950.1

    UniProtKB/TrEMBL
    A6HGX5
    Related
    ENSRNOP00000083587.2, ENSRNOT00000118502.2
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 465
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:344 → 386
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006246885.5 → XP_006246947.1  coronin-6 isoform X1

    See identical proteins and their annotated locations for XP_006246947.1

    UniProtKB/Swiss-Prot
    Q4G087, Q920J3
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 466
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:344 → 386
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006246887.5 → XP_006246949.1  coronin-6 isoform X3

    See identical proteins and their annotated locations for XP_006246949.1

    UniProtKB/TrEMBL
    A6HGX6
    Related
    ENSRNOP00000019759.4, ENSRNOT00000019759.8
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 465
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:344 → 386
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_006246889.5 → XP_006246951.1  coronin-6 isoform X5

    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 426
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:304 → 346
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006246890.5 → XP_006246952.1  coronin-6 isoform X6

    See identical proteins and their annotated locations for XP_006246952.1

    UniProtKB/TrEMBL
    A0A8L2RAN5, A6HGX7
    Related
    ENSRNOP00000075615.2, ENSRNOT00000086706.3
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 425
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:304 → 346
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_005489689.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920J3.2 GenPept UniProtKB/Swiss-Prot:Q920J3

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