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Lmo1 LIM domain only 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245979, updated on 9-Dec-2024

Summary

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Official Symbol
Lmo1provided by RGD
Official Full Name
LIM domain only 1provided by RGD
Primary source
RGD:621166
See related
EnsemblRapid:ENSRNOG00000014629 AllianceGenome:RGD:621166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dat1
Summary
Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and regulation of T cell homeostatic proliferation. Predicted to be active in nucleus. Orthologous to human LMO1 (LIM domain only 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 41.0), Brain (RPKM 35.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lmo1 in Genome Data Viewer
Location:
1q33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172567156..172603282, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163132338..163168521, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (173728183..173764288, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TUB bipartite transcription factor Neighboring gene high mobility group protein B1 pseudogene Neighboring gene RIC3 acetylcholine receptor chaperone Neighboring gene uncharacterized LOC120097351 Neighboring gene serine/threonine kinase 33 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha GSU) gene. Susa T, et al. Biosci Rep, 2009 Oct 9. PMID 19228115
  2. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. McGuire EA, et al. Mol Cell Biol, 1992 Sep. PMID 1508213, Free PMC Article
  3. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. McGuire EA, et al. Blood, 1991 Feb 1. PMID 1703797
  4. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Chervinsky DS, et al. Mol Cell Biol, 1999 Jul. PMID 10373552, Free PMC Article
  5. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. Kusy S, et al. J Exp Med, 2010 Sep 27. PMID 20855495, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell homeostatic proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of T cell homeostatic proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LIM domain only protein 3
Names
LIM domain only protein 1
dopamine-inducible LIM-domain transcription factor DAT1
neuronal-specific transcription factor DAT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402442.1 → NP_001389371.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A0A0G2K422, A6I7V8
    Related
    ENSRNOP00000072872.1, ENSRNOT00000086944.3

  2. NM_139112.3 → NP_620812.2  LIM domain only protein 3 isoform 2

    See identical proteins and their annotated locations for NP_620812.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A6I7V7, D4A8W2
    Related
    ENSRNOP00000019690.5, ENSRNOT00000019690.7
    Conserved Domains (2) summary
    cd09388
    Location:23 → 77
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:87 → 141
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    172567156..172603282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229968.3 → XP_006230030.1  LIM domain only protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006230030.1

    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A0A0G2K422, A6I7V8
    Conserved Domains (2) summary
    cd09388
    Location:24 → 78
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:88 → 142
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  2. XM_039098644.2 → XP_038954572.1  LIM domain only protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A6I7V9
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  3. XM_063280885.1 → XP_063136955.1  LIM domain only protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A6I7V9

  4. XM_039098608.2 → XP_038954536.1  LIM domain only protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q99MB5
    UniProtKB/TrEMBL
    A0A8I5ZW30
    Related
    ENSRNOP00000083193.1, ENSRNOT00000093951.2
    Conserved Domains (2) summary
    cd09388
    Location:19 → 73
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:83 → 137
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MB5.2 GenPept UniProtKB/Swiss-Prot:Q99MB5

Gene LinkOut

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