Adgrf5 adhesion G protein-coupled receptor F5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrf5provided by RGD
Official Full Name: adhesion G protein-coupled receptor F5provided by RGD
Primary source: RGD:621679
See related: EnsemblRapid:ENSRNOG00000011154 AllianceGenome:RGD:621679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr116; Gprhep; Ig-Hepta
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy reserve metabolic process; and fat cell differentiation. Predicted to act upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Predicted to be located in apical part of cell and cell surface. Predicted to be active in cytoplasmic vesicle. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1414.6), Heart (RPKM 382.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (25014861..25128045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17517596..17624107, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20091121..20195706, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D9Got23 (e-PCR)
- UniSTS:112911

D9Wox36 (e-PCR)
- UniSTS:518515

D9Got26 (e-PCR)
- UniSTS:114553

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within energy reserve metabolic process	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glomerular filtration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor F5

Names: G protein-coupled hepta-helical receptor Ig-Hepta; G-protein coupled hepta-helical receptor Ig-hepta; G-protein coupled receptor 116; probable G-protein coupled receptor 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139110.2 → NP_620810.1 adhesion G protein-coupled receptor F5 precursor

See identical proteins and their annotated locations for NP_620810.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9WVT0

UniProtKB/TrEMBL

A6JJ39

Related

ENSRNOP00000015223.1, ENSRNOT00000015223.4

Conserved Domains (6) summary

smart00408
Location:283 → 351

IGc2; Immunoglobulin C-2 Type

smart00410
Location:475 → 560

IG_like; Immunoglobulin like

pfam00047
Location:473 → 550

ig; Immunoglobulin domain

pfam01390
Location:166 → 252

SEA; SEA domain

pfam01825
Location:952 → 999

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:1014 → 1265

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

25014861..25128045 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266632.1 → XP_063122702.1 adhesion G protein-coupled receptor F5 isoform X6
XM_063266631.1 → XP_063122701.1 adhesion G protein-coupled receptor F5 isoform X6
XM_008766833.4 → XP_008765055.1 adhesion G protein-coupled receptor F5 isoform X6

See identical proteins and their annotated locations for XP_008765055.1

Related

ENSRNOP00000102120.1, ENSRNOT00000135806.1

Conserved Domains (6) summary

smart00410
Location:537 → 622

IG_like; Immunoglobulin like

pfam00047
Location:535 → 612

ig; Immunoglobulin domain

pfam01390
Location:166 → 252

SEA; SEA domain

pfam01825
Location:1014 → 1061

GPS; GPCR proteolysis site, GPS, motif

cl11960
Location:283 → 351

Ig; Immunoglobulin domain

cl21561
Location:1076 → 1327

7tm_4; Olfactory receptor
XM_008766832.4 → XP_008765054.1 adhesion G protein-coupled receptor F5 isoform X6

See identical proteins and their annotated locations for XP_008765054.1

Conserved Domains (6) summary

smart00410
Location:537 → 622

IG_like; Immunoglobulin like

pfam00047
Location:535 → 612

ig; Immunoglobulin domain

pfam01390
Location:166 → 252

SEA; SEA domain

pfam01825
Location:1014 → 1061

GPS; GPCR proteolysis site, GPS, motif

cl11960
Location:283 → 351

Ig; Immunoglobulin domain

cl21561
Location:1076 → 1327

7tm_4; Olfactory receptor
XM_039083014.2 → XP_038938942.1 adhesion G protein-coupled receptor F5 isoform X5

Conserved Domains (7) summary

smart00409
Location:298 → 372

IG; Immunoglobulin

pfam01390
Location:181 → 273

SEA; SEA domain

pfam01825
Location:1029 → 1076

GPS; GPCR proteolysis site, GPS, motif

pfam13927
Location:548 → 621

Ig_3; Immunoglobulin domain

cd00096
Location:548 → 551

Ig; Ig strand A [structural motif]

cd14964
Location:1091 → 1116

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1090 → 1363

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039083012.1 → XP_038938940.1 adhesion G protein-coupled receptor F5 isoform X2

UniProtKB/TrEMBL

A0A0G2JZZ0

Related

ENSRNOP00000071238.2, ENSRNOT00000082904.3

Conserved Domains (7) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam01390
Location:166 → 258

SEA; SEA domain

pfam01825
Location:992 → 1039

GPS; GPCR proteolysis site, GPS, motif

pfam13927
Location:511 → 584

Ig_3; Immunoglobulin domain

cd00096
Location:511 → 514

Ig; Ig strand A [structural motif]

cd14964
Location:1054 → 1079

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1053 → 1326

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039083013.1 → XP_038938941.1 adhesion G protein-coupled receptor F5 isoform X4

Conserved Domains (7) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam01390
Location:166 → 258

SEA; SEA domain

pfam01825
Location:974 → 1021

GPS; GPCR proteolysis site, GPS, motif

pfam13927
Location:493 → 566

Ig_3; Immunoglobulin domain

cd00096
Location:493 → 496

Ig; Ig strand A [structural motif]

cd14964
Location:1036 → 1061

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1035 → 1308

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063266630.1 → XP_063122700.1 adhesion G protein-coupled receptor F5 isoform X3

UniProtKB/TrEMBL

A0A8I6AR34

Related

ENSRNOP00000096657.1, ENSRNOT00000118179.2
XM_008766834.4 → XP_008765056.1 adhesion G protein-coupled receptor F5 isoform X1

Conserved Domains (6) summary

smart00410
Location:537 → 622

IG_like; Immunoglobulin like

pfam00047
Location:535 → 612

ig; Immunoglobulin domain

pfam01390
Location:166 → 252

SEA; SEA domain

pfam01825
Location:1014 → 1061

GPS; GPCR proteolysis site, GPS, motif

cl11960
Location:283 → 351

Ig; Immunoglobulin domain

cl21561
Location:1076 → 1327

7tm_4; Olfactory receptor