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Atp5f1d ATP synthase F1 subunit delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 245965, updated on 27-Nov-2024

Summary

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Official Symbol
Atp5f1dprovided by RGD
Official Full Name
ATP synthase F1 subunit deltaprovided by RGD
Primary source
RGD:621372
See related
EnsemblRapid:ENSRNOG00000014625 AllianceGenome:RGD:621372
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5d
Summary
Contributes to ATP hydrolysis activity. Involved in response to resveratrol. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex, catalytic core F(1). Used to study obesity. Biomarker of colitis and myocardial infarction. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 508.9), Muscle (RPKM 355.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp5f1d in Genome Data Viewer
Location:
7q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10211260..10218989, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9560604..9565919, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12426807..12432120, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cold inducible RNA binding protein Neighboring gene midnolin Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11 Neighboring gene uncharacterized LOC134479811

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Delta subunit of rat liver mitochondrial ATP synthase: molecular description and novel insights into the nature of its association with the F1-moiety. Pan W, et al. Biochemistry, 1998 May 12. PMID 9578578
  2. Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms. Tu L, et al. Microcirculation, 2013 Nov. PMID 23809007
  3. A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet. Arias N, et al. Obesity (Silver Spring), 2017 Jan. PMID 27874268
  4. Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions. Chen JR, et al. Drug Des Devel Ther, 2015. PMID 26109848, Free PMC Article
  5. Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis. Luan A, et al. Environ Toxicol Pharmacol, 2015 May. PMID 25880160

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to resveratrol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit delta, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
F-ATPase delta subunit
NP_620806.2
XP_006240907.1
XP_063119057.1
XP_063119058.1
XP_063119059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139106.2 → NP_620806.2  ATP synthase subunit delta, mitochondrial precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P35434
    UniProtKB/TrEMBL
    A6K8Q6
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10211260..10218989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262988.1 → XP_063119058.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    G3V7Y3

  2. XM_006240845.4 → XP_006240907.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    G3V7Y3
    Related
    ENSRNOP00000020670.2, ENSRNOT00000020670.6
    Conserved Domains (2) summary
    cd12152
    Location:99 → 223
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit
    COG0355
    Location:98 → 228
    AtpC; FoF1-type ATP synthase, epsilon subunit [Energy production and conversion]

  3. XM_063262989.1 → XP_063119059.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    G3V7Y3

  4. XM_063262987.1 → XP_063119057.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    G3V7Y3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35434.2 GenPept UniProtKB/Swiss-Prot:P35434

Gene LinkOut

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