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invs inversin [ Danio rerio (zebrafish) ]

Gene ID: 245946, updated on 9-Dec-2024

Summary

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Official Symbol
invsprovided by ZNC
Official Full Name
inversinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020507-2
See related
Ensembl:ENSDARG00000002213 AllianceGenome:ZFIN:ZDB-GENE-020507-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fe47e11
Summary
Predicted to enable calmodulin binding activity. Acts upstream of or within several processes, including cloaca development; morphogenesis of an epithelium; and opsin transport. Located in cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See invs in Genome Data Viewer
Location:
chromosome: 16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (27442539..27502697)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (27507923..27568341)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene syntaxin 17 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene uncharacterized LOC137487909 Neighboring gene testis expressed 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Wang H, et al. Biochem Biophys Res Commun, 2023 Sep 17. PMID 37352572
  2. The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish. Fukui H, et al. FEBS Lett, 2012 Jul 30. PMID 22687244
  3. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Simons M, et al. Nat Genet, 2005 May. PMID 15852005, Free PMC Article
  4. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Otto EA, et al. Nat Genet, 2003 Aug. PMID 12872123, Free PMC Article
  5. Nephrocystin-3 is required for ciliary function in zebrafish embryos. Zhou W, et al. Am J Physiol Renal Physiol, 2010 Jul. PMID 20462968, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation.
    Title: Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation.
  2. Nek8 acts downstream of Inv function
    Title: The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cloaca development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within opsin transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within opsin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephros formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephros morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to ciliary inversin compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inversin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152970.1 → NP_694502.1  inversin

    See identical proteins and their annotated locations for NP_694502.1

    Status: PROVISIONAL

    Source sequence(s)
    AF465261
    UniProtKB/Swiss-Prot
    Q8UVC1
    Related
    ENSDARP00000014904.8, ENSDART00000015688.10
    Conserved Domains (4) summary
    cd00204
    Location:377 → 502
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:420 → 509
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:482 → 537
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:415 → 446
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    27442539..27502697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158039.5 → XP_005158096.1  inversin isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4V4
    Conserved Domains (5) summary
    cd00204
    Location:378 → 503
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12446
    Location:722 → 836
    DUF3682; Protein of unknown function (DUF3682)
    pfam12796
    Location:421 → 510
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:483 → 538
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:416 → 447
    ANK; ANK repeat [structural motif]

  2. XM_068213882.1 → XP_068069983.1  inversin isoform X2

    Related
    ENSDARP00000133199.2, ENSDART00000157690.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8UVC1.1 GenPept UniProtKB/Swiss-Prot:Q8UVC1

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