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insrb insulin receptor b [ Danio rerio (zebrafish) ]

Gene ID: 245700, updated on 9-Dec-2024

Summary

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Official Symbol
insrbprovided by ZNC
Official Full Name
insulin receptor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020503-4
See related
Ensembl:ENSDARG00000071524 AllianceGenome:ZFIN:ZDB-GENE-020503-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
IRb; sb:eu666; si:dkey-6n3.1
Summary
Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within chordate embryonic development; developmental growth; and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See insrb in Genome Data Viewer
Location:
chromosome: 22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10927871..11053148, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10898189..11023466, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene ectodermal-neural cortex 3 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18b Neighboring gene uncharacterized LOC100148254 Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of insulin receptor signaling in zebrafish embryogenesis. Toyoshima Y, et al. Endocrinology, 2008 Dec. PMID 18687786, Free PMC Article
  2. Persistent impaired glucose metabolism in a zebrafish hyperglycemia model. Capiotti KM, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 May. PMID 24704522
  3. (1)H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene. Benchoula K, et al. Sci Rep, 2024 Feb 15. PMID 38360784, Free PMC Article
  4. Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio). Capiotti KM, et al. Behav Brain Res, 2014 Nov 1. PMID 25157430
  5. Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action. Liu C, et al. Sci Rep, 2017 May 17. PMID 28515443, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insra and Insrb exhibit diversified functions in maintaining glucose homeostasis in zebrafish.
    Title: Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
insulin receptor b
NP_001116701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123229.1 → NP_001116701.1  insulin receptor b precursor

    See identical proteins and their annotated locations for NP_001116701.1

    Status: PROVISIONAL

    Source sequence(s)
    BX666064, BX908744
    UniProtKB/TrEMBL
    B7SNG5, Q1LVG4
    Related
    ENSDARP00000096601.4, ENSDART00000105823.6
    Conserved Domains (6) summary
    cd05061
    Location:982 → 1269
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:606 → 649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:226 → 273
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:173 → 329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:348 → 462
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:989 → 1256
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    10927871..11053148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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