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Sipa1l2 signal-induced proliferation-associated 1 like 2 [ Mus musculus (house mouse) ]

Gene ID: 244668, updated on 27-Nov-2024

Summary

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Official Symbol
Sipa1l2provided by MGI
Official Full Name
signal-induced proliferation-associated 1 like 2provided by MGI
Primary source
MGI:MGI:2676970
See related
Ensembl:ENSMUSG00000001995 AllianceGenome:MGI:2676970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1389
Summary
Predicted to enable GTPase activator activity. Involved in presynaptic signal transduction. Is active in glutamatergic synapse. Is expressed in brain and thymus primordium. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.0), lung adult (RPKM 16.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Sipa1l2 in Genome Data Viewer
Location:
8 E2; 8 73.63 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126144807..126296602, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125418068..125569863, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127591083-127591270 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127591569-127591752 Neighboring gene VISTA enhancer mm1749 Neighboring gene disrupted in schizophrenia 1 Neighboring gene VISTA enhancer mm149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127817421-127817530 Neighboring gene STARR-seq mESC enhancer starr_23015 Neighboring gene STARR-seq mESC enhancer starr_23016 Neighboring gene STARR-seq mESC enhancer starr_23018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:127915206-127915507 Neighboring gene STARR-seq mESC enhancer starr_23020 Neighboring gene predicted gene, 30713 Neighboring gene STARR-seq mESC enhancer starr_23022 Neighboring gene RIKEN cDNA 4930566D17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:128084754-128084863 Neighboring gene RIKEN cDNA 4930567H12 gene Neighboring gene predicted gene, 51602 Neighboring gene STARR-seq mESC enhancer starr_23041 Neighboring gene STARR-seq mESC enhancer starr_23042 Neighboring gene predicted gene, 30871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testing SIPA1L2 as a modifier of CMT1A using mouse models. Murray GC, et al. J Neuropathol Exp Neurol, 2024 Apr 19. PMID 38472136,
  2. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Andres-Alonso M, et al. Nat Commun, 2019 Nov 29. PMID 31784514, Free PMC Article
  3. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Wajapeyee N, et al. Genes Dev, 2013 Oct 15. PMID 24105743, Free PMC Article
  4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testing SIPA1L2 as a modifier of CMT1A using mouse models.
    Title: Testing SIPA1L2 as a modifier of CMT1A using mouse models.
  2. SIPA1L2, which connects TrkB amphisomes to a dynein motor, orchestrates neuronal amphisomal trafficking of BDNF/TrkB at presynaptic boutons during retrograde transport to the soma.
    Title: SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in presynaptic signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
signal-induced proliferation-associated 1-like protein 2
Names
SIPA1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081337.2 → NP_001074806.1  signal-induced proliferation-associated 1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001074806.1

    Status: VALIDATED

    Source sequence(s)
    AC073946
    Consensus CDS
    CCDS40518.1
    UniProtKB/Swiss-Prot
    E9QPK7, Q6PDY1, Q80TE4
    UniProtKB/TrEMBL
    B9EK76
    Related
    ENSMUSP00000104405.2, ENSMUST00000108775.2
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1666
    SPAR_C; C-terminal domain of SPAR protein

  2. NM_001357372.1 → NP_001344301.1  signal-induced proliferation-associated 1-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BB352643, BC072593, CJ105938
    Consensus CDS
    CCDS90484.1
    UniProtKB/TrEMBL
    A0A1D5RLY9, B9EK76
    Related
    ENSMUSP00000148557.2, ENSMUST00000212168.2
    Conserved Domains (4) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1648
    SPAR_C; C-terminal domain of SPAR protein
    pfam15742
    Location:1630 → 1694
    DUF4686; Domain of unknown function (DUF4686)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    126144807..126296602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248389.1 → XP_011246691.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

    UniProtKB/TrEMBL
    B9EK76
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1604
    SPAR_C; C-terminal domain of SPAR protein

  2. XM_006531024.1 → XP_006531087.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531087.1

    UniProtKB/Swiss-Prot
    E9QPK7, Q6PDY1, Q80TE4
    UniProtKB/TrEMBL
    B9EK76
    Related
    ENSMUSP00000148536.2, ENSMUST00000212987.2
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1666
    SPAR_C; C-terminal domain of SPAR protein

  3. XM_030243567.2 → XP_030099427.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E9QPK7, Q6PDY1, Q80TE4
    UniProtKB/TrEMBL
    B9EK76
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1666
    SPAR_C; C-terminal domain of SPAR protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TE4.3 GenPept UniProtKB/Swiss-Prot:Q80TE4

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