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Mrgpre MAS-related GPR, member E [ Mus musculus (house mouse) ]

Gene ID: 244238, updated on 27-Nov-2024

Summary

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Official Symbol
Mrgpreprovided by MGI
Official Full Name
MAS-related GPR, member Eprovided by MGI
Primary source
MGI:MGI:2441884
See related
Ensembl:ENSMUSG00000048965 AllianceGenome:MGI:2441884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgrf; MrgE; Ebrt3; C130069N09Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cartilage; eye; genitourinary system; and nervous system. Orthologous to human MRGPRE (MAS related GPR family member E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 3.2), CNS E18 (RPKM 3.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mrgpre in Genome Data Viewer
Location:
7 F5; 7 88.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143332100..143338237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143778363..143784500, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G Neighboring gene NAD synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1750 Neighboring gene STARR-positive B cell enhancer ABC_E2257 Neighboring gene STARR-positive B cell enhancer ABC_E3763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:151023918-151024190 Neighboring gene 7-dehydrocholesterol reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility. Xu M, et al. Exp Physiol, 2021 Dec. PMID 34647371
  2. The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice. Cox PJ, et al. Mol Pain, 2008 Jan 15. PMID 18197975, Free PMC Article
  3. The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum. Avula LR, et al. Histochem Cell Biol, 2011 Nov. PMID 21912971
  4. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
  5. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility.
    Title: Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility.
  2. The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis.
    Title: The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum.
  3. The data suggests that MrgE may play a role in selective pain behavioural responses in mice.
    Title: The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member E
Names
G protein-coupled receptor MrgE
Mas-related G protein-coupled receptor f
evolutionary breakpoint transcript 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175534.3 → NP_780743.1  mas-related G-protein coupled receptor member E

    See identical proteins and their annotated locations for NP_780743.1

    Status: VALIDATED

    Source sequence(s)
    AJ320231, AK133657, CD807098
    Consensus CDS
    CCDS22046.1
    UniProtKB/Swiss-Prot
    Q711I9, Q91ZB7
    UniProtKB/TrEMBL
    Q4V9R2
    Related
    ENSMUSP00000058000.9, ENSMUST00000054048.10
    Conserved Domains (1) summary
    cd15112
    Location:43 → 292
    7tmA_MrgprE; mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143332100..143338237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153126.1 → XP_036009019.1  mas-related G-protein coupled receptor member E isoform X1

    UniProtKB/Swiss-Prot
    Q711I9, Q91ZB7
    UniProtKB/TrEMBL
    Q4V9R2
    Conserved Domains (1) summary
    cd15112
    Location:43 → 292
    7tmA_MrgprE; mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZB7.1 GenPept UniProtKB/Swiss-Prot:Q91ZB7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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