Gad1 glutamate decarboxylase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gad1provided by RGD
Official Full Name: glutamate decarboxylase 1provided by RGD
Primary source: RGD:2652
See related: EnsemblRapid:ENSRNOG00000000007 AllianceGenome:RGD:2652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gad67
Summary: Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including cellular response to serotonin; gamma-aminobutyric acid biosynthetic process; and positive regulation of locomotion involved in locomotory behavior. Located in neuronal cell body and presynaptic active zone. Used to study diabetes mellitus. Biomarker of several diseases, including autism spectrum disorder; drug psychosis; morphine dependence; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 455.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (75777260..75818099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (55369704..55410335)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (56861440..56902139)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging.
Title: Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging.
Age-related changes in glutamic acid decarboxylase 1 gene expression in the medial prefrontal cortex and ventral hippocampus of fear-potentiated rats subjected to isolation stress.
Title: Age-related changes in glutamic acid decarboxylase 1 gene expression in the medial prefrontal cortex and ventral hippocampus of fear-potentiated rats subjected to isolation stress.
Parvalbumin in the metabolic pathway of glutamate and gamma-aminobutyric acid: Influence on expression of GAD65 and GAD67.
Title: Parvalbumin in the metabolic pathway of glutamate and γ-aminobutyric acid: Influence on expression of GAD65 and GAD67.
Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67.
Title: Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67.
The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure.
Title: The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure.
Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats.
Title: Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats.
Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
Title: Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
Profile of miR-23 Expression and Possible Role in Regulation of Glutamic Acid Decarboxylase during Postnatal Retinal Development.
Title: Profile of miR-23 Expression and Possible Role in Regulation of Glutamic Acid Decarboxylase during Postnatal Retinal Development.
GAD67 expression is impaired in the brain of schizophrenia-related WISKET rats.
Title: Impaired GAD1 expression in schizophrenia-related WISKET rat model with sex-dependent aggressive behavior and motivational deficit.
Prenatal caffeine exposure induced a high expression of hippocampal GAD67 in rats.
Title: High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gad1 (e-PCR), detects polymorphism
- UniSTS:143160

Gad1 (e-PCR), detects polymorphism
- UniSTS:265661

Gad1 (e-PCR), detects polymorphism
- UniSTS:265662

PMC30678P2 (e-PCR)
- UniSTS:272577

Gad1 (e-PCR), detects polymorphism
- UniSTS:507874

Gad1 (e-PCR), detects polymorphism
- UniSTS:507875

Z49976 (e-PCR)
- UniSTS:125937

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables glutamate decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables glutamate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to serotonin	IEP Inferred from Expression Pattern more info	PubMed
involved_in gamma-aminobutyric acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caloric restriction	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to isolation stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methamphetamine hydrochloride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IEA Inferred from Electronic Annotation more info
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate decarboxylase 1

Names: 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 variant GAD67NT; glutamic acid decarboxylase 1

NP_058703.1

EC 4.1.1.15

XP_017446943.1

EC 4.1.1.15

XP_038960170.1

EC 4.1.1.15

XP_063139145.1

EC 4.1.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017007.2 → NP_058703.1 glutamate decarboxylase 1

See identical proteins and their annotated locations for NP_058703.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P18088

UniProtKB/TrEMBL

A0A0G2K7I5, C9E895

Related

ENSRNOP00000000008.3, ENSRNOT00000000008.6

Conserved Domains (1) summary

pfam00282
Location:143 → 517

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

75777260..75818099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283075.1 → XP_063139145.1 glutamate decarboxylase 1 isoform X1

UniProtKB/Swiss-Prot

P18088

UniProtKB/TrEMBL

C9E895

Related

ENSRNOP00000103968.1, ENSRNOT00000164935.1
XM_017591454.3 → XP_017446943.1 glutamate decarboxylase 1 isoform X1

UniProtKB/Swiss-Prot

P18088

UniProtKB/TrEMBL

A0A0G2K7I5, C9E895

Conserved Domains (1) summary

pfam00282
Location:143 → 517

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
XM_039104242.2 → XP_038960170.1 glutamate decarboxylase 1 isoform X2

UniProtKB/TrEMBL

B3VQJ0

Conserved Domains (1) summary

pfam00282
Location:1 → 368

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain