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Iqsec3 IQ motif and Sec7 domain 3 [ Mus musculus (house mouse) ]

Gene ID: 243621, updated on 4-Jan-2025

Summary

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Official Symbol
Iqsec3provided by MGI
Official Full Name
IQ motif and Sec7 domain 3provided by MGI
Primary source
MGI:MGI:2677208
See related
Ensembl:ENSMUSG00000040797 AllianceGenome:MGI:2677208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRAG3; mKIAA1110; synarfGEF
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; postsynapse organization; and regulation of small GTPase mediated signal transduction. Located in inhibitory synapse; postsynaptic density; and postsynaptic membrane. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization of symmetric synapse. Is expressed in endocrine gland; male reproductive gland or organ; and nervous system. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in frontal lobe adult (RPKM 20.3), cortex adult (RPKM 14.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Iqsec3 in Genome Data Viewer
Location:
6 F1; 6 57.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121349886..121450697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (121372927..121473738, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 13 Neighboring gene STARR-positive B cell enhancer ABC_E6482 Neighboring gene solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Neighboring gene STARR-seq mESC enhancer starr_17212 Neighboring gene STARR-seq mESC enhancer starr_17213 Neighboring gene STARR-seq mESC enhancer starr_17214 Neighboring gene voltage-dependent anion-selective channel protein 2 pseudogene Neighboring gene alpha-2-macroglobulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior. Kim S, et al. Cell Rep, 2021 Jul 20. PMID 34289353
  2. Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina. Sakagami H, et al. J Comp Neurol, 2013 Mar 1. PMID 22886754
  3. Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus. Kim S, et al. Cell Rep, 2020 Feb 11. PMID 32049026
  4. SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. Fukaya M, et al. J Neurochem, 2011 Mar. PMID 21198641
  5. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
    Title: Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
  2. Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.
    Title: Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.
  3. BRAG2 localized to postsynaptic processes at bipolar dyads, while BRAG3 localized to postsynaptic components at conventional synapses in mouse retina
    Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization of symmetric synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
IQ motif and SEC7 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033354.4 → NP_001028526.1  IQ motif and SEC7 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001028526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC115799, AC153982
    Consensus CDS
    CCDS20491.1
    UniProtKB/Swiss-Prot
    Q3TES0, Q3UHP8, Q80TJ8
    Related
    ENSMUSP00000038653.6, ENSMUST00000046373.8
    Conserved Domains (2) summary
    cd13318
    Location:870 → 1000
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:655 → 843
    Sec7; Sec7 domain

  2. NM_001289685.2 → NP_001276614.1  IQ motif and SEC7 domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC115799, AC153982
    Conserved Domains (2) summary
    cd13318
    Location:570 → 700
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:355 → 543
    Sec7; Sec7 domain

  3. NM_001411678.1 → NP_001398607.1  IQ motif and SEC7 domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115799, AC153982

  4. NM_001411679.1 → NP_001398608.1  IQ motif and SEC7 domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115799, AC153982

RNA

  1. NR_110358.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 2 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC115799, AC153982
    Related
    ENSMUST00000129815.8

  2. NR_177449.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115799, AC153982

  3. NR_177450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115799, AC153982

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    121349886..121450697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506112.4 → XP_006506175.1  IQ motif and SEC7 domain-containing protein 3 isoform X2

    Conserved Domains (4) summary
    PRK12323
    Location:122 → 287
    PRK12323; DNA polymerase III subunit gamma/tau
    cd14686
    Location:32 → 63
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    pfam01369
    Location:655 → 843
    Sec7; Sec7 domain
    pfam16453
    Location:863 → 995
    IQ_SEC7_PH; PH domain

  2. XM_030255387.2 → XP_030111247.1  IQ motif and SEC7 domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    Q3UHJ6
    Conserved Domains (2) summary
    pfam01369
    Location:355 → 543
    Sec7; Sec7 domain
    pfam16453
    Location:563 → 695
    IQ_SEC7_PH; PH domain

  3. XM_006506113.5 → XP_006506176.1  IQ motif and SEC7 domain-containing protein 3 isoform X3

    Conserved Domains (4) summary
    PRK12323
    Location:122 → 287
    PRK12323; DNA polymerase III subunit gamma/tau
    cd14686
    Location:32 → 63
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    pfam01369
    Location:655 → 843
    Sec7; Sec7 domain
    pfam16453
    Location:863 → 995
    IQ_SEC7_PH; PH domain

RNA

  1. XR_004942952.1 RNA Sequence

  2. XR_004942953.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TES0.1 GenPept UniProtKB/Swiss-Prot:Q3TES0

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