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Fancc FA complementation group C [ Rattus norvegicus (Norway rat) ]

Gene ID: 24361, updated on 2-Nov-2024

Summary

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Symbol
Fanccprovided by RGD
Full Name
FA complementation group Cprovided by RGD
Primary source
RGD:2593
See related
EnsemblRapid:ENSRNOG00000016889 AllianceGenome:RGD:2593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Facc
Summary
Predicted to be involved in cellular response to oxidative stress and nucleotide-excision repair. Predicted to act upstream of or within several processes, including brain morphogenesis; neuronal stem cell population maintenance; and removal of superoxide radicals. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; aspirin-induced respiratory disease; pancreatic cancer; and pancytopenia. Orthologous to human FANCC (FA complementation group C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 46.8), Thymus (RPKM 44.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fancc in Genome Data Viewer
Location:
17p14
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1686374..1818672)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1680660..1822610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (826512..955703, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene uncharacterized LOC134482656 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene aminopeptidase O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Carreau M, et al. Blood, 1998 Apr 15. PMID 9531583
  2. Phenotypic correction of Fanconi anemia group C knockout mice. Gush KA, et al. Blood, 2000 Jan 15. PMID 10627482
  3. Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia. Barber LM, et al. Br J Haematol, 2003 Apr. PMID 12670332
  4. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein. Gavish H, et al. Hum Mol Genet, 1993 Feb. PMID 8499901
  5. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Li J, et al. Antioxid Redox Signal, 2012 Oct 15. PMID 22482891, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in brain morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
  
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
  
involved_in myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fanconi anaemia nuclear complex IEA
Inferred from Electronic Annotation
more info
  
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
  
part_of Fanconi anaemia nuclear complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Fanconi anemia group C protein homolog
Names
Fanconi anemia, complementation group C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012557.2 → NP_036689.2  Fanconi anemia group C protein homolog

    See identical proteins and their annotated locations for NP_036689.2

    Status: PROVISIONAL

    Source sequence(s)
    BC168147
    UniProtKB/Swiss-Prot
    O35870
    UniProtKB/TrEMBL
    B4F762
    Related
    ENSRNOP00000101125.1, ENSRNOT00000164718.1
    Conserved Domains (1) summary
    pfam02106
    Location:10 → 554
    Fanconi_C; Fanconi anaemia group C protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    1686374..1818672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276053.1 → XP_063132123.1  Fanconi anemia group C protein homolog isoform X5

  2. XM_006253489.5 → XP_006253551.1  Fanconi anemia group C protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006253551.1

    UniProtKB/Swiss-Prot
    O35870
    UniProtKB/TrEMBL
    B4F762
    Related
    ENSRNOP00000022884.6, ENSRNOT00000022884.8
    Conserved Domains (1) summary
    pfam02106
    Location:10 → 554
    Fanconi_C; Fanconi anaemia group C protein

  3. XM_063276051.1 → XP_063132121.1  Fanconi anemia group C protein homolog isoform X2

    UniProtKB/TrEMBL
    B4F762

  4. XM_063276050.1 → XP_063132120.1  Fanconi anemia group C protein homolog isoform X2

    UniProtKB/TrEMBL
    B4F762

  5. XM_063276049.1 → XP_063132119.1  Fanconi anemia group C protein homolog isoform X1

  6. XM_063276052.1 → XP_063132122.1  Fanconi anemia group C protein homolog isoform X4

  7. XM_006253491.5 → XP_006253553.1  Fanconi anemia group C protein homolog isoform X3

    UniProtKB/Swiss-Prot
    O35870
    Conserved Domains (1) summary
    pfam02106
    Location:24 → 463
    Fanconi_C; Fanconi anaemia group C protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35870.1 GenPept UniProtKB/Swiss-Prot:O35870

Gene LinkOut

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