U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chrnb1 cholinergic receptor nicotinic beta 1 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 24261, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Chrnb1provided by RGD
Official Full Name
cholinergic receptor nicotinic beta 1 subunitprovided by RGD
Primary source
RGD:2349
See related
EnsemblRapid:ENSRNOG00000014698 AllianceGenome:RGD:2349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acrb; nAChR; RNACRB1
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 126.3), Kidney (RPKM 20.2) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chrnb1 in Genome Data Viewer
Location:
10q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54999943..55015137, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54501096..54516418, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56390671..56403255, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit A Neighboring gene solute carrier family 35, member G3 Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene fibroblast growth factor 11 Neighboring gene transmembrane protein 102

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome. Gomez CM, et al. Ann Neurol, 1996 Jun. PMID 8651643
  2. Effect of Inhibiting p38 on HuR Involving in β-AChR Post-transcriptional Mechanisms in Denervated Skeletal Muscle. Wang H, et al. Cell Mol Neurobiol, 2019 Oct. PMID 31172341
  3. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Lou XY, et al. Hum Genet, 2006 Oct. PMID 16874522
  4. CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. Phillips HA, et al. Am J Hum Genet, 2001 Jan. PMID 11104662, Free PMC Article
  5. Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit. Ohno K, et al. Proc Natl Acad Sci U S A, 1995 Jan 31. PMID 7531341, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. inhibition of p38 can post-transcriptionally inhibit beta-AChR upregulation via HuR in denervated skeletal muscle.
    Title: Effect of Inhibiting p38 on HuR Involving in β-AChR Post-transcriptional Mechanisms in Denervated Skeletal Muscle.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine binding IEA
Inferred from Electronic Annotation
more info
  
enables acetylcholine binding ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables channel activity ISO
Inferred from Sequence Orthology
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in behavioral response to nicotine IEA
Inferred from Electronic Annotation
more info
  
involved_in behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acetylcholine receptor subunit beta
Names
Acetylcholine receptor beta
cholinergic receptor nicotinic beta polypeptide 1
cholinergic receptor, nicotinic beta 1
cholinergic receptor, nicotinic, beta 1 (muscle)
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
n acetylcholine receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395118.3 → NP_001382047.1  acetylcholine receptor subunit beta isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AYT8, A0A8L2UJI2
    Conserved Domains (2) summary
    cd19024
    Location:27 → 248
    LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
    pfam02932
    Location:255 → 490
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001429878.1 → NP_001416807.1  acetylcholine receptor subunit beta isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  3. NM_001429879.1 → NP_001416808.1  acetylcholine receptor subunit beta isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_012528.4 → NP_036660.1  acetylcholine receptor subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_036660.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P25109
    UniProtKB/TrEMBL
    A0A8I6AYT8, A6HFT8
    Related
    ENSRNOP00000089285.2, ENSRNOT00000110050.2
    Conserved Domains (3) summary
    TIGR00860
    Location:24 → 488
    LIC; Cation transporter family protein
    pfam02931
    Location:27 → 245
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:252 → 487
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54999943..55015137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085172.2 → XP_038941100.1  acetylcholine receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I6AYT8, A0A8L2UJI2
    Conserved Domains (2) summary
    cd19024
    Location:27 → 248
    LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
    pfam02932
    Location:255 → 490
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. XM_039085174.2 → XP_038941102.1  acetylcholine receptor subunit beta isoform X3

    Conserved Domains (3) summary
    cd19024
    Location:27 → 245
    LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
    cd03559
    Location:246 → 270
    LGIC_TM; TM1 helix [structural motif]
    cl38911
    Location:246 → 273
    LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels

  3. XM_039085173.2 → XP_038941101.1  acetylcholine receptor subunit beta isoform X2

    Conserved Domains (3) summary
    cd19024
    Location:27 → 248
    LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
    cd03559
    Location:249 → 273
    LGIC_TM; TM1 helix [structural motif]
    cl38911
    Location:249 → 276
    LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25109.1 GenPept UniProtKB/Swiss-Prot:P25109

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools