U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnai4 dynein axonemal intermediate chain 4 [ Mus musculus (house mouse) ]

Gene ID: 242584, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dnai4provided by MGI
Official Full Name
dynein axonemal intermediate chain 4provided by MGI
Primary source
MGI:MGI:2385328
See related
Ensembl:ENSMUSG00000035126 AllianceGenome:MGI:2385328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr78
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in axonemal dynein complex assembly and cilium movement. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axoneme and motile cilium. Part of axonemal dynein complex. Is expressed in brain and olfactory epithelium. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 5.9), testis adult (RPKM 5.6) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dnai4 in Genome Data Viewer
Location:
4 C6; 4 47.28 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102891954..102971524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103038065..103114299, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102737628-102737949 Neighboring gene MEIR1 treanscription regulator Neighboring gene STARR-seq mESC enhancer starr_10936 Neighboring gene solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 Neighboring gene RIKEN cDNA 4921539E11 gene Neighboring gene STARR-seq mESC enhancer starr_10938 Neighboring gene STARR-seq mESC enhancer starr_10939

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC31722, MGC38950

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of axonemal dynein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal intermediate chain 4
Names
WD repeat domain 78
WD repeat-containing protein 78
dynein intermediate chain 4, axonemal

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425039.1 → NP_001411968.1  dynein axonemal intermediate chain 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844176

  2. NM_146254.5 → NP_666366.4  dynein axonemal intermediate chain 4 isoform 1

    See identical proteins and their annotated locations for NP_666366.4

    Status: VALIDATED

    Source sequence(s)
    AL844176
    Consensus CDS
    CCDS38824.3
    UniProtKB/Swiss-Prot
    E9PYY5, Q8C0I9, Q8K042, Q8K111
    Related
    ENSMUSP00000102481.4, ENSMUST00000106868.4
    Conserved Domains (2) summary
    COG2319
    Location:444 → 790
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:498 → 542
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_189044.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844176

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102891954..102971524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164129.1 → XP_036020022.1  dynein axonemal intermediate chain 4 isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:444 → 792
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:498 → 542
    7WD40; WD40 repeat [structural motif]

  2. XM_030253560.2 → XP_030109420.1  dynein axonemal intermediate chain 4 isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:401 → 749
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:455 → 499
    7WD40; WD40 repeat [structural motif]

  3. XM_030253559.2 → XP_030109419.1  dynein axonemal intermediate chain 4 isoform X2

    Conserved Domains (2) summary
    COG2319
    Location:441 → 763
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:469 → 513
    7WD40; WD40 repeat [structural motif]

  4. XM_030253561.1 → XP_030109421.1  dynein axonemal intermediate chain 4 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:314 → 662
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:368 → 412
    7WD40; WD40 repeat [structural motif]

  5. XM_030253562.2 → XP_030109422.1  dynein axonemal intermediate chain 4 isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:195 → 543
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:249 → 293
    7WD40; WD40 repeat [structural motif]

  6. XM_017320218.3 → XP_017175707.1  dynein axonemal intermediate chain 4 isoform X8

  7. XM_006503078.5 → XP_006503141.1  dynein axonemal intermediate chain 4 isoform X7

  8. XM_006503077.5 → XP_006503140.1  dynein axonemal intermediate chain 4 isoform X6

RNA

  1. XR_004941896.1 RNA Sequence

  2. XR_376319.5 RNA Sequence

  3. XR_004941895.1 RNA Sequence

  4. XR_376318.4 RNA Sequence

    Related
    ENSMUST00000116316.10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PYY5.1 GenPept UniProtKB/Swiss-Prot:E9PYY5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools