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Manea mannosidase, endo-alpha [ Mus musculus (house mouse) ]

Gene ID: 242362, updated on 27-Nov-2024

Summary

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Official Symbol
Maneaprovided by MGI
Official Full Name
mannosidase, endo-alphaprovided by MGI
Primary source
MGI:MGI:2444484
See related
Ensembl:ENSMUSG00000040520 AllianceGenome:MGI:2444484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932703L02Rik
Summary
Predicted to enable glycoprotein endo-alpha-1,2-mannosidase activity. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 3.9), cerebellum adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Manea in Genome Data Viewer
Location:
4 A3; 4 10.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (26324506..26346913, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (26324506..26346918, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hematological and neurological expressed 1 pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09794 Neighboring gene STARR-seq mESC enhancer starr_09795 Neighboring gene STARR-seq mESC enhancer starr_09796 Neighboring gene predicted gene, 24965 Neighboring gene STARR-seq mESC enhancer starr_09797 Neighboring gene STARR-seq mESC enhancer starr_09798 Neighboring gene STARR-seq mESC enhancer starr_09802 Neighboring gene STARR-positive B cell enhancer ABC_E7957 Neighboring gene STARR-positive B cell enhancer ABC_E10227 Neighboring gene STARR-seq mESC enhancer starr_09803 Neighboring gene betaine-homocysteine methyltransferase, pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycoprotein endo-alpha-1,2-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycoprotein endo-alpha-1,2-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycoprotein endo-alpha-1,2-mannosidase
Names
endo-alpha mannosidase
endomannosidase
mEndo
NP_001398666.1
NP_001398675.1
NP_766453.2
XP_006537962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411737.1 → NP_001398666.1  glycoprotein endo-alpha-1,2-mannosidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL805949

  2. NM_001411746.1 → NP_001398675.1  glycoprotein endo-alpha-1,2-mannosidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL805949

  3. NM_172865.3 → NP_766453.2  glycoprotein endo-alpha-1,2-mannosidase isoform 1

    See identical proteins and their annotated locations for NP_766453.2

    Status: VALIDATED

    Source sequence(s)
    AL805949
    Consensus CDS
    CCDS18012.1
    UniProtKB/Swiss-Prot
    Q6NXH2, Q8C0N9
    Related
    ENSMUSP00000038671.8, ENSMUST00000041374.8
    Conserved Domains (1) summary
    pfam16317
    Location:98 → 448
    Glyco_hydro_99; Glycosyl hydrolase family 99

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    26324506..26346913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537899.5 → XP_006537962.1  glycoprotein endo-alpha-1,2-mannosidase isoform X1

    See identical proteins and their annotated locations for XP_006537962.1

    UniProtKB/Swiss-Prot
    Q6NXH2, Q8C0N9
    Conserved Domains (1) summary
    pfam16317
    Location:98 → 448
    Glyco_hydro_99; Glycosyl hydrolase family 99
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXH2.1 GenPept UniProtKB/Swiss-Prot:Q6NXH2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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