Bdnf brain-derived neurotrophic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bdnfprovided by RGD
Official Full Name: brain-derived neurotrophic factorprovided by RGD
Primary source: RGD:2202
See related: EnsemblRapid:ENSRNOG00000047466 AllianceGenome:RGD:2202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and secretory vesicle. Used to study several diseases, including alcohol dependence; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; anxiety disorder (multiple); and attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in several diseases, including cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); and obstructive sleep apnea. Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 34.1), Lung (RPKM 27.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (116619633..116670212)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (96165042..96215621)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (100768637..100819216)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic Pathways in Ageing Neuromuscular Synapses.
Title: Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic Pathways in Ageing Neuromuscular Synapses.
The Inflammation/NF-kappaB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat.
Title: The Inflammation/NF-κB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat.
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder.
Title: Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder.
An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons.
Title: An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons.
Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons.
Title: Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons.
Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.
Title: Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.
Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus.
Title: Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus.
Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.
Title: Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.
Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.
Title: Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.
BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance.
Title: BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance.

Submit: New GeneRIF Correction See all GeneRIFs (940)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BDNF (e-PCR)
- UniSTS:266531

UniSTS:463961 (e-PCR)
- UniSTS:463961

Bdnf (e-PCR), detects polymorphism
- UniSTS:463961

Bdnf (e-PCR), detects polymorphism
- UniSTS:256883

Bdnf (e-PCR), detects polymorphism
- UniSTS:530821

D3Mgh28 (e-PCR)
- UniSTS:240275

D3Arb11 (e-PCR)
- UniSTS:239509

BE101548 (e-PCR)
- UniSTS:243609

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin TRKB receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon target recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to norepinephrine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in cognition	IEP Inferred from Expression Pattern more info	PubMed
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mechanoreceptor differentiation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection extension	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of retinal cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to anesthetic	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nerve growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within taste bud development	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: brain-derived neurotrophic factor

Names: brain derived neurothrophic factor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270630.1 → NP_001257559.1 brain-derived neurotrophic factor isoform 1

See identical proteins and their annotated locations for NP_001257559.1

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as VI) encodes the longest isoform (1).

Source sequence(s)

CN544668, EF125680

UniProtKB/TrEMBL

A0A0H2UI28, A6HP02

Related

ENSRNOP00000064356.2, ENSRNOT00000073636.4

Conserved Domains (1) summary

smart00140
Location:248 → 355

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270631.1 → NP_001257560.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257560.1

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as IIC) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125678

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Related

ENSRNOP00000072849.1, ENSRNOT00000077703.3

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270632.1 → NP_001257561.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257561.1

Status: VALIDATED

Description

Transcript Variant: This variant (4, also known as IIB) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125677

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270633.1 → NP_001257562.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257562.1

Status: VALIDATED

Description

Transcript Variant: This variant (5, also known as IV) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125679

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Related

ENSRNOP00000073265.1, ENSRNOT00000080190.3

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270634.1 → NP_001257563.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257563.1

Status: VALIDATED

Description

Transcript Variant: This variant (6, also known as 6B) has an alternate 5' exon and an additional exon in the 5' region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

AY559250, CN544668, EF125689

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270635.1 → NP_001257564.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257564.1

Status: VALIDATED

Description

Transcript Variant: This variant (7, also known as III) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125686

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Related

ENSRNOP00000075479.1, ENSRNOT00000089233.3

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270636.1 → NP_001257565.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257565.1

Status: VALIDATED

Description

Transcript Variant: This variant (8, also known as VII or 6A) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125688

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270637.1 → NP_001257566.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257566.1

Status: VALIDATED

Description

Transcript Variant: This variant (9, also known as IIA) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125676

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001270638.1 → NP_001257567.1 brain-derived neurotrophic factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001257567.1

Status: VALIDATED

Description

Transcript Variant: This variant (10, also known as V) has an alternate 5' exon and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-10 encode the same isoform 3.

Source sequence(s)

CN544668, EF125687

UniProtKB/Swiss-Prot

P23363, Q53YL8

UniProtKB/TrEMBL

A6HP04

Related

ENSRNOP00000072315.1, ENSRNOT00000078543.3

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_012513.4 → NP_036645.2 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_036645.2

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as I) has an alternate 5' exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

CN544668, EF125675

UniProtKB/TrEMBL

A0A0G2K624, A6HP01

Related

ENSRNOP00000073647.1, ENSRNOT00000083542.3

Conserved Domains (1) summary

smart00140
Location:143 → 250

NGF; Nerve growth factor (NGF or beta-NGF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

116619633..116670212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234684.5 → XP_006234746.1 brain-derived neurotrophic factor isoform X1

Related

ENSRNOP00000104100.1, ENSRNOT00000122945.1

Conserved Domains (1) summary

smart00140
Location:162 → 269

NGF; Nerve growth factor (NGF or beta-NGF)