Atp4b ATPase H+/K+ transporting subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp4bprovided by RGD
Official Full Name: ATPase H+/K+ transporting subunit betaprovided by RGD
Primary source: RGD:2178
See related: EnsemblRapid:ENSRNOG00000018543 AllianceGenome:RGD:2178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S76401S1
Summary: Contributes to heterocyclic compound binding activity. Involved in pH reduction and response to lipopolysaccharide. Predicted to be located in apical plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Used to study obesity. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82846329..82855242)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76144150..76153063)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81136218..81145131, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study on N-terminally truncated beta-variants of the gastric H,K-ATPase provides direct evidence that the beta-N terminus assists in E2P state stabilization and that this is critical for the transport efficiency of the enzyme under in vivo conditions.
Title: E2P state stabilization by the N-terminal tail of the H,K-ATPase beta-subunit is critical for efficient proton pumping under in vivo conditions.
The substitution of 5 amino acids in the low affinity ouabain binding site of non-gastric proton-potassium exchanging ATPase in order to increase ouabain binding affinity is reported.
Title: Conversion of the low affinity ouabain-binding site of non-gastric H,K-ATPase into a high affinity binding site by substitution of only five amino acids.
Non-gastric H,K-ATPase is oligomycin-sensitive and can function as H+,NH4(+)-ATPase.
Title: The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase.

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General gene information

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Markers

RH94695 (e-PCR)
- UniSTS:119942

D16Mco8 (e-PCR)
- UniSTS:239249

D16Wox17 (e-PCR)
- UniSTS:240554

D16Arb12 (e-PCR)
- UniSTS:239591

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
part_of potassium:proton exchanging ATPase complex	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium-transporting ATPase subunit beta

Names: ATPase H+/K+ transporting beta subunit; ATPase H+K+-transporting beta / (gastric HK-ATPase beta subunit) defined by SSR; ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR; ATPase, H+/K+ exchanging, beta polypeptide; ATPase, H+/K+ transporting, beta polypeptide; gastric H(+)/K(+) ATPase subunit beta; proton pump beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012510.2 → NP_036642.2 potassium-transporting ATPase subunit beta

See identical proteins and their annotated locations for NP_036642.2

Status: PROVISIONAL

Source sequence(s)

M35535

UniProtKB/Swiss-Prot

P18598

UniProtKB/TrEMBL

A6IWH6

Related

ENSRNOP00000025957.1, ENSRNOT00000025958.4

Conserved Domains (1) summary

TIGR01107
Location:2 → 294

Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

82846329..82855242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094190.1 → XP_038950118.1 potassium-transporting ATPase subunit beta isoform X1

Conserved Domains (1) summary

TIGR01107
Location:2 → 289

Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit