Atp1b2 ATPase Na+/K+ transporting subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp1b2provided by RGD
Official Full Name: ATPase Na+/K+ transporting subunit beta 2provided by RGD
Primary source: RGD:2171
See related: EnsemblRapid:ENSRNOG00000011227 AllianceGenome:RGD:2171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amog; ATPB2; ATPB2S; RATATPB2S
Summary: Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Predicted to be involved in several processes, including intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and positive regulation of cation transmembrane transport. Predicted to act upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in apical plasma membrane. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 145.9), Brain (RPKM 117.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54817473..54823708, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54318698..54324933, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56205622..56211879, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered expression levels of miR-144-3p and ATP1B2 are associated with schizophrenia.
Title: Altered expression levels of miR-144-3p and ATP1B2 are associated with schizophrenia.
From the data the authors assume that activation of (Pro) renin receptor (P)RR and V-ATPase may play an important role in tubulointerstitial fibrosis with possible involvement of interaction of V-ATPase B2 subunit and (P)RR.
Title: Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis.
Preferential concentration of beta(1)-subunit in caveolae was cell specific; it was also noted in neonatal cardiac myocytes but not in fibroblasts and A7r5 cells.
Title: Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae.
Chronic heart failure-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by exercise training.
Title: Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	IEA Inferred from Electronic Annotation more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lateral ventricle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lateral ventricle development	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glial cell migration	ISO Inferred from Sequence Orthology more info
involved_in neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane bounded cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within plasma membrane bounded cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in third ventricle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within third ventricle development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte end-foot	IEA Inferred from Electronic Annotation more info
located_in astrocyte end-foot	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in cell body membrane	IEA Inferred from Electronic Annotation more info
located_in cell body membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron to neuron synapse	IEA Inferred from Electronic Annotation more info
located_in neuron to neuron synapse	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info
part_of sodium:potassium-exchanging ATPase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit beta-2

Names: ATPase, Na+/K+ transporting, beta 2 polypeptide; ATPase, Na+K+ transporting, beta polypeptide 2; sodium/potassium-dependent ATPase subunit beta-2

NP_036639.2

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.