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Asgr1 asialoglycoprotein receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24210, updated on 27-Nov-2024

Summary

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Official Symbol
Asgr1provided by RGD
Official Full Name
asialoglycoprotein receptor 1provided by RGD
Primary source
RGD:2160
See related
EnsemblRapid:ENSRNOG00000018693 AllianceGenome:RGD:2160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ASGR; RHL1; RATRHL1
Summary
Enables asialoglycoprotein receptor activity. Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR1 (asialoglycoprotein receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1684.1) See more
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Genomic context

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See Asgr1 in Genome Data Viewer
Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55274299..55278323)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54775727..54779642)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56662188..56666086)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene transfer RNA threonine (anticodon AGU) 28 Neighboring gene SEC61 translocon subunit gamma like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles. Li Y, et al. Contrast Media Mol Imaging, 2021. PMID 34131415, Free PMC Article
  2. Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats. Casey CA, et al. J Appl Physiol (1985), 2004 Jan. PMID 12949020
  3. Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Holland EC, et al. Proc Natl Acad Sci U S A, 1984 Dec. PMID 6095287, Free PMC Article
  4. Characterization of the gene encoding the major rat liver asialoglycoprotein receptor. Leung JO, et al. J Biol Chem, 1985 Oct 15. PMID 2995379
  5. Isolation and expression of cDNA clones for a rat liver asialoglycoprotein receptor. Watts C. Biosci Rep, 1986 Jun. PMID 2945599

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles.
    Title: Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles.
  2. a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content.
    Title: Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats.
  3. Asialoglycoprotein receptor functions to help regulate the concentration of glycoproteins bearing sialic acid alpha 2,6GalNAc in the blood.
    Title: The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAc.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108731

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asialoglycoprotein receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
asialoglycoprotein receptor 1
Names
ASGP-R 1
ASGPR 1
Asialoglycoprotein receptor 1 (hepatic lectin)
HL-1
RHL-1
asialoglycoprotein receptor (RHL1)
hepatic lectin 1, RHL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429873.1 → NP_001416802.1  asialoglycoprotein receptor 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P02706
    UniProtKB/TrEMBL
    A6HG16

  2. NM_001429874.1 → NP_001416803.1  asialoglycoprotein receptor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  3. NM_001429875.1 → NP_001416804.1  asialoglycoprotein receptor 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_012503.2 → NP_036635.1  asialoglycoprotein receptor 1 isoform a

    See identical proteins and their annotated locations for NP_036635.1

    Status: VALIDATED

    Source sequence(s)
    BC088154
    UniProtKB/Swiss-Prot
    P02706
    UniProtKB/TrEMBL
    A6HG15, A6HG16
    Conserved Domains (2) summary
    cd03590
    Location:153 → 278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:15 → 143
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55274299..55278323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085168.2 → XP_038941096.1  asialoglycoprotein receptor 1 isoform X1

    Conserved Domains (2) summary
    cd03590
    Location:153 → 278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:15 → 143
    Lectin_N; Hepatic lectin, N-terminal domain

  2. XM_008767769.4 → XP_008765991.1  asialoglycoprotein receptor 1 isoform X2

    See identical proteins and their annotated locations for XP_008765991.1

    UniProtKB/TrEMBL
    A6HG15
    Conserved Domains (2) summary
    cd03590
    Location:149 → 274
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18 → 139
    Lectin_N; Hepatic lectin, N-terminal domain

  3. XM_006246579.2 → XP_006246641.1  asialoglycoprotein receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006246641.1

    UniProtKB/Swiss-Prot
    P02706
    UniProtKB/TrEMBL
    A6HG15, A6HG16
    Related
    ENSRNOP00000025254.3, ENSRNOT00000025254.7
    Conserved Domains (2) summary
    cd03590
    Location:153 → 278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:15 → 143
    Lectin_N; Hepatic lectin, N-terminal domain

  4. XM_008767768.3 → XP_008765990.1  asialoglycoprotein receptor 1 isoform X2

    Conserved Domains (2) summary
    cd03590
    Location:149 → 274
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18 → 139
    Lectin_N; Hepatic lectin, N-terminal domain

  5. XM_039085170.2 → XP_038941098.1  asialoglycoprotein receptor 1 isoform X3

    Conserved Domains (2) summary
    cd03590
    Location:53 → 178
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:1 → 43
    Lectin_N; Hepatic lectin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02706.2 GenPept UniProtKB/Swiss-Prot:P02706

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