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Ubl3 ubiquitin-like 3 [ Mus musculus (house mouse) ]

Gene ID: 24109, updated on 27-Nov-2024

Summary

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Official Symbol
Ubl3provided by MGI
Official Full Name
ubiquitin-like 3provided by MGI
Primary source
MGI:MGI:1344373
See related
Ensembl:ENSMUSG00000001687 AllianceGenome:MGI:1344373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HCG; MUB; mmMUB
Summary
Predicted to be located in plasma membrane. Orthologous to human UBL3 (ubiquitin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 50.1), cerebellum adult (RPKM 42.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubl3 in Genome Data Viewer
Location:
5 G3; 5 88.66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (148441441..148489689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (148504631..148552879, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene STARR-seq mESC enhancer starr_14908 Neighboring gene STARR-seq mESC enhancer starr_14912 Neighboring gene predicted gene, 35735 Neighboring gene predicted gene, 35994 Neighboring gene predicted gene, 35929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UBL3 modification influences protein sorting to small extracellular vesicles. Ageta H, et al. Nat Commun, 2018 Sep 26. PMID 30258067, Free PMC Article
  2. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. Chadwick BP, et al. Gene, 1999 Jun 11. PMID 10375635
  3. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. Downes BP, et al. J Biol Chem, 2006 Sep 15. PMID 16831869
  4. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. Liu H, et al. Nat Commun, 2022 Apr 11. PMID 35411049, Free PMC Article
  5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
    Title: Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-like protein 3
Names
membrane-anchored ubiquitin-fold protein
protein HCG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359199.1 → NP_001346128.1  ubiquitin-like protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC157990, AC158302
    Consensus CDS
    CCDS39403.1
    UniProtKB/Swiss-Prot
    A4FTW0, Q3UKM1, Q9Z2M6
    UniProtKB/TrEMBL
    Q3UYL1
    Related
    ENSMUSP00000131049.2, ENSMUST00000164904.2
    Conserved Domains (1) summary
    cd17048
    Location:10 → 91
    Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins

  2. NM_001359200.1 → NP_001346129.1  ubiquitin-like protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AC157990, CA574503
    Conserved Domains (1) summary
    cl28922
    Location:1 → 47
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. NM_001359201.1 → NP_001346130.1  ubiquitin-like protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AC157990, AC158302
    Conserved Domains (1) summary
    cl28922
    Location:1 → 47
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. NM_001359202.1 → NP_001346131.1  ubiquitin-like protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AC157990, AC158302
    Conserved Domains (1) summary
    cl28922
    Location:1 → 47
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. NM_011908.2 → NP_036038.1  ubiquitin-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_036038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK145952, AV226728, BU059122, CK794503, DV661495
    Consensus CDS
    CCDS39403.1
    UniProtKB/Swiss-Prot
    A4FTW0, Q3UKM1, Q9Z2M6
    UniProtKB/TrEMBL
    Q3UYL1
    Related
    ENSMUSP00000078303.8, ENSMUST00000079324.14
    Conserved Domains (1) summary
    cd17048
    Location:10 → 91
    Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    148441441..148489689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504832.4 → XP_006504895.1  ubiquitin-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006504895.1

    UniProtKB/Swiss-Prot
    A4FTW0, Q3UKM1, Q9Z2M6
    UniProtKB/TrEMBL
    Q3UYL1
    Related
    ENSMUSP00000144073.2, ENSMUST00000201595.4
    Conserved Domains (1) summary
    cd17048
    Location:10 → 91
    Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2M6.1 GenPept UniProtKB/Swiss-Prot:Q9Z2M6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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