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St18 suppression of tumorigenicity 18 [ Mus musculus (house mouse) ]

Gene ID: 240690, updated on 27-Nov-2024

Summary

Official Symbol
St18provided by MGI
Official Full Name
suppression of tumorigenicity 18provided by MGI
Primary source
MGI:MGI:2446700
See related
Ensembl:ENSMUSG00000033740 AllianceGenome:MGI:2446700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myt3; Nzf3; NZF-3; mKIAA0535
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; eye; foregut-midgut junction; future brain; and olfactory epithelium. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 6.1), CNS E11.5 (RPKM 3.2) and 5 other tissues See more
Orthologs
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Genomic context

See St18 in Genome Data Viewer
Location:
1 A1; 1 1.89 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (6557455..6931164)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (6487231..6860940)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ALK and LTK ligand 1 Neighboring gene STARR-positive B cell enhancer ABC_E8980 Neighboring gene STARR-seq mESC enhancer starr_00081 Neighboring gene uncharacterized protein C9orf40 homolog pseudogene Neighboring gene motile sperm domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00082 Neighboring gene STARR-seq mESC enhancer starr_00083 Neighboring gene STARR-seq mESC enhancer starr_00085 Neighboring gene STARR-seq mESC enhancer starr_00086 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00087 Neighboring gene STARR-seq mESC enhancer starr_00089 Neighboring gene predicted gene, 37108 Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
suppression of tumorigenicity 18 protein
Names
neural zinc finger protein NZF-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244692.1NP_001231621.1  suppression of tumorigenicity 18 protein

    See identical proteins and their annotated locations for NP_001231621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AK122303, AK147320, BC032273
    Consensus CDS
    CCDS14810.1
    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Related
    ENSMUSP00000118322.2, ENSMUST00000140079.8
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  2. NM_001244693.1NP_001231622.1  suppression of tumorigenicity 18 protein

    See identical proteins and their annotated locations for NP_001231622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK122303, AK147320, BC032273
    Consensus CDS
    CCDS14810.1
    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Related
    ENSMUSP00000117789.2, ENSMUST00000131494.8
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  3. NM_173868.2NP_776293.1  suppression of tumorigenicity 18 protein

    See identical proteins and their annotated locations for NP_776293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses different sequence for its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AJ536155, AK137440
    Consensus CDS
    CCDS14810.1
    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Related
    ENSMUSP00000122055.2, ENSMUST00000151281.8
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA

RNA

  1. NR_045188.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ536155
  2. NR_045189.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ536155, BC118528

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    6557455..6931164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164681.1XP_036020574.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  2. XM_036164683.1XP_036020576.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  3. XM_036164670.1XP_036020563.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  4. XM_036164682.1XP_036020575.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Related
    ENSMUSP00000131417.3, ENSMUST00000163727.4
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  5. XM_011238372.3XP_011236674.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_011236674.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  6. XM_030253959.1XP_030109819.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  7. XM_030253967.1XP_030109827.1  suppression of tumorigenicity 18 protein isoform X3

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:730758
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:445678
    MYT1; Myelin transcription factor 1
    cl01483
    Location:886969
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  8. XM_030253964.2XP_030109824.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Related
    ENSMUSP00000042056.7, ENSMUST00000043578.13
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  9. XM_006495503.5XP_006495566.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_006495566.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  10. XM_011238371.4XP_011236673.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_011236673.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  11. XM_030253957.2XP_030109817.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  12. XM_030253968.2XP_030109828.1  suppression of tumorigenicity 18 protein isoform X3

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:730758
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:445678
    MYT1; Myelin transcription factor 1
    cl01483
    Location:886969
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  13. XM_030253955.2XP_030109815.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  14. XM_036164684.1XP_036020577.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  15. XM_006495501.4XP_006495564.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_006495564.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  16. XM_036164671.1XP_036020564.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  17. XM_036164680.1XP_036020573.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  18. XM_030253956.1XP_030109816.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  19. XM_011238373.3XP_011236675.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_011236675.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  20. XM_030253960.1XP_030109820.1  suppression of tumorigenicity 18 protein isoform X1

    UniProtKB/TrEMBL
    A5LFV3
    Conserved Domains (3) summary
    pfam01530
    Location:772800
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:487720
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9281011
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  21. XM_006495504.4XP_006495567.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_006495567.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  22. XM_006495502.5XP_006495565.1  suppression of tumorigenicity 18 protein isoform X2

    See identical proteins and their annotated locations for XP_006495565.1

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  23. XM_030253961.2XP_030109821.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
  24. XM_030253963.2XP_030109823.1  suppression of tumorigenicity 18 protein isoform X2

    UniProtKB/Swiss-Prot
    Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
    UniProtKB/TrEMBL
    A5LFV3, Q148A0
    Conserved Domains (3) summary
    pfam01530
    Location:765793
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:480713
    MYT1; Myelin transcription factor 1
    cl01483
    Location:9211004
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA