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Srp54a signal recognition particle 54A [ Mus musculus (house mouse) ]

Gene ID: 24067, updated on 27-Nov-2024

Summary

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Official Symbol
Srp54aprovided by MGI
Official Full Name
signal recognition particle 54Aprovided by MGI
Primary source
MGI:MGI:1346087
See related
Ensembl:ENSMUSG00000073079 AllianceGenome:MGI:1346087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
54kDa; Srp54
Summary
Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane, translocation; exocrine pancreas development; and neutrophil chemotaxis. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 34.3), bladder adult (RPKM 29.5) and 26 other tissues See more
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Genomic context

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See Srp54a in Genome Data Viewer
Location:
12 C1; 12 23.86 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55127318..55162152)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55080476..55115367)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700097O09 gene Neighboring gene predicted gene, 46350 Neighboring gene RNA polymerase II, polypeptide H Neighboring gene family with sequence similarity 177, member A Neighboring gene predicted gene 2436 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56256085-56256386 Neighboring gene signal recognition particle 54B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. Zopf D, et al. EMBO J, 1990 Dec. PMID 1702385, Free PMC Article
  2. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Bernstein HD, et al. Nature, 1989 Aug 10. PMID 2502718
  3. Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Halic M, et al. Nature, 2004 Feb 26. PMID 14985753
  4. Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles. Takenaka M, et al. Kidney Int, 1998 Mar. PMID 9507200
  5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endoplasmic reticulum signal peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endoplasmic reticulum signal peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocrine pancreas development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle 54 kDa protein
Names
54K subunit of signal recognition particle
signal recognition particle subunit SRP54
NP_001400559.1
NP_001400560.1
NP_001400561.1
NP_001400562.1
NP_036029.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413630.1 → NP_001400559.1  signal recognition particle 54 kDa protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157515

  2. NM_001413631.1 → NP_001400560.1  signal recognition particle 54 kDa protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157515

  3. NM_001413632.1 → NP_001400561.1  signal recognition particle 54 kDa protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157515

  4. NM_001413633.1 → NP_001400562.1  signal recognition particle 54 kDa protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157515
    UniProtKB/Swiss-Prot
    P14576, Q3UWX8, Q9CWH7, Q9D008
    Related
    ENSMUSP00000021407.11, ENSMUST00000021407.11

  5. NM_011899.5 → NP_036029.2  signal recognition particle 54 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_036029.2

    Status: VALIDATED

    Source sequence(s)
    AC157515
    Consensus CDS
    CCDS36449.1
    UniProtKB/Swiss-Prot
    P14576, Q3UWX8, Q9CWH7, Q9D008
    UniProtKB/TrEMBL
    Q8C1Y6
    Related
    ENSMUSP00000152764.2, ENSMUST00000220578.2
    Conserved Domains (1) summary
    TIGR01425
    Location:2 → 430
    SRP54_euk; signal recognition particle protein SRP54

RNA

  1. NR_182177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157515

  2. NR_182178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157515

  3. NR_182179.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157515

  4. NR_182180.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157515

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55127318..55162152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14576.2 GenPept UniProtKB/Swiss-Prot:P14576

Gene LinkOut

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