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Slc16a12 solute carrier family 16 (monocarboxylic acid transporters), member 12 [ Mus musculus (house mouse) ]

Gene ID: 240638, updated on 27-Nov-2024

Summary

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Official Symbol
Slc16a12provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 12provided by MGI
Primary source
MGI:MGI:2147716
See related
Ensembl:ENSMUSG00000009378 AllianceGenome:MGI:2147716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT 12; 3230401A21
Summary
Predicted to enable creatine transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; and uniporter activity. Predicted to be involved in creatine transmembrane transport and creatinine metabolic process. Located in basolateral plasma membrane. Is expressed in several structures, including brain ventricle and choroid plexus; endocardial tissue; metanephros; olfactory epithelium; and pancreas. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 20.0), liver adult (RPKM 8.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Slc16a12 in Genome Data Viewer
Location:
19 C1; 19 29.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34645801..34725223, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34668401..34747493, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18425 Neighboring gene STARR-seq mESC enhancer starr_46002 Neighboring gene STARR-seq mESC enhancer starr_46003 Neighboring gene STARR-seq mESC enhancer starr_46004 Neighboring gene predicted gene, 22082 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. Dhayat N, et al. J Am Soc Nephrol, 2016 May. PMID 26376857, Free PMC Article
  2. Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane. Castorino JJ, et al. Invest Ophthalmol Vis Sci, 2011 Aug 29. PMID 21778275, Free PMC Article
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency.
    Title: Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables creatine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables creatine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uniporter activity ISO
Inferred from Sequence Orthology
more info
  
enables uniporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in creatine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in creatine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in creatine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in creatinine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in creatinine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172838.4 → NP_766426.1  monocarboxylate transporter 12

    Status: VALIDATED

    Source sequence(s)
    AC016791, AC125259
    Consensus CDS
    CCDS29767.1
    UniProtKB/Swiss-Prot
    Q14CF9, Q14DR7, Q8BGC3
    Related
    ENSMUSP00000009522.4, ENSMUST00000009522.4
    Conserved Domains (1) summary
    cd17424
    Location:18 → 431
    MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34645801..34725223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527078.5 → XP_006527141.1  monocarboxylate transporter 12 isoform X1

    UniProtKB/Swiss-Prot
    Q14CF9, Q14DR7, Q8BGC3
    Conserved Domains (1) summary
    cd17424
    Location:18 → 431
    MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters

  2. XM_011247246.3 → XP_011245548.1  monocarboxylate transporter 12 isoform X1

    UniProtKB/Swiss-Prot
    Q14CF9, Q14DR7, Q8BGC3
    Conserved Domains (1) summary
    cd17424
    Location:18 → 431
    MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters

  3. XM_006527079.4 → XP_006527142.1  monocarboxylate transporter 12 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:22 → 416
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGC3.1 GenPept UniProtKB/Swiss-Prot:Q8BGC3

Gene LinkOut

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