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Zfp438 zinc finger protein 438 [ Mus musculus (house mouse) ]

Gene ID: 240186, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp438provided by MGI
Official Full Name
zinc finger protein 438provided by MGI
Primary source
MGI:MGI:2444919
See related
Ensembl:ENSMUSG00000050945 AllianceGenome:MGI:2444919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430031G09; 9430091M14Rik; B830013J05Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; gonad; limb; and ureter. Orthologous to human ZNF438 (zinc finger protein 438). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 12.1), bladder adult (RPKM 1.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp438 in Genome Data Viewer
Location:
18 A1; 18 3.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (5210027..5334826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (5210027..5334826, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43692 Neighboring gene predicted gene, 53196 Neighboring gene STARR-seq mESC enhancer starr_43693 Neighboring gene predicted gene, 26682 Neighboring gene STARR-seq mESC enhancer starr_43694 Neighboring gene STARR-positive B cell enhancer mm9_chr18:5334784-5335085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:5347140-5347323 Neighboring gene predicted gene, 52372 Neighboring gene predicted gene, 34630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 438

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360447.1 → NP_001347376.1  zinc finger protein 438

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC111128, AC133945
    Consensus CDS
    CCDS37721.1
    UniProtKB/TrEMBL
    Q8BFX2, Q8BXJ4
    Related
    ENSMUSP00000156983.2, ENSMUST00000234241.2
    Conserved Domains (3) summary
    sd00017
    Location:495 → 515
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:521 → 543
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:507 → 532
    zf-H2C2_2; Zinc-finger double domain

  2. NM_178722.5 → NP_848837.3  zinc finger protein 438

    See identical proteins and their annotated locations for NP_848837.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034745, AK046812
    Consensus CDS
    CCDS37721.1
    UniProtKB/TrEMBL
    Q8BFX2, Q8BXJ4
    Related
    ENSMUSP00000067049.6, ENSMUST00000063989.7
    Conserved Domains (3) summary
    sd00017
    Location:495 → 515
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:521 → 543
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:507 → 532
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    5210027..5334826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161137.1 → XP_036017030.1  zinc finger protein 438 isoform X2

    UniProtKB/TrEMBL
    Q8BXJ4
    Conserved Domains (2) summary
    sd00017
    Location:430 → 450
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:456 → 478
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_011246916.2 → XP_011245218.1  zinc finger protein 438 isoform X1

    See identical proteins and their annotated locations for XP_011245218.1

    UniProtKB/TrEMBL
    Q8BFX2, Q8BXJ4
    Conserved Domains (3) summary
    sd00017
    Location:495 → 515
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:521 → 543
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:507 → 532
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036161136.1 → XP_036017029.1  zinc finger protein 438 isoform X2

    UniProtKB/TrEMBL
    Q8BXJ4
    Conserved Domains (2) summary
    sd00017
    Location:430 → 450
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:456 → 478
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein Strain
Heading Accession and Version

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