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Cadm2 cell adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 239857, updated on 27-Nov-2024

Summary

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Official Symbol
Cadm2provided by MGI
Official Full Name
cell adhesion molecule 2provided by MGI
Primary source
MGI:MGI:2442722
See related
Ensembl:ENSMUSG00000064115 AllianceGenome:MGI:2442722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NECL3; Igdf4d; Igsf4d; SynCAM2; SynCAM 2; 9330131D06; 2900078E11Rik; A830029E02Rik
Summary
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in axon. Predicted to be active in neuronal cell body membrane. Is expressed in bone; central nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 12.4), cortex adult (RPKM 11.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Cadm2 in Genome Data Viewer
Location:
16 C1.3- C2; 16 37.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (66452302..67417825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (66655416..67620917, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22448 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41177 Neighboring gene STARR-seq mESC enhancer starr_41178 Neighboring gene STARR-seq mESC enhancer starr_41179 Neighboring gene STARR-seq mESC enhancer starr_41180 Neighboring gene RIKEN cDNA 1700010K23 gene Neighboring gene STARR-seq mESC enhancer starr_41181 Neighboring gene STARR-seq mESC enhancer starr_41182 Neighboring gene predicted gene, 57633 Neighboring gene STARR-seq mESC enhancer starr_41183 Neighboring gene STARR-seq mESC enhancer starr_41184 Neighboring gene STARR-seq mESC enhancer starr_41185 Neighboring gene STARR-seq mESC enhancer starr_41186 Neighboring gene STARR-seq mESC enhancer starr_41187 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41188 Neighboring gene STARR-seq mESC enhancer starr_41189 Neighboring gene predicted gene, 24681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Necl2/3-mediated mechanism for tripartite synapse formation. Nozawa O, et al. Development, 2023 Feb 15. PMID 36458527
  2. Cadm2 regulates body weight and energy homeostasis in mice. Yan X, et al. Mol Metab, 2018 Feb. PMID 29217450, Free PMC Article
  3. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Sanchez-Roige S, et al. Transl Psychiatry, 2023 May 12. PMID 37173343, Free PMC Article
  4. Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons. Sukhanov N, et al. J Neurosci, 2021 Feb 17. PMID 33397712, Free PMC Article
  5. Axoglial Adhesion by Cadm4 Regulates CNS Myelination. Elazar N, et al. Neuron, 2019 Jan 16. PMID 30551998, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.
    Title: CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.
  2. Cadm2 expression regulates body weight and glucose homeostasis.
    Title: Cadm2 regulates body weight and energy homeostasis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell adhesion molecule 2
Names
NECL-3
immunoglobulin superfamily member 4D
immunoglobulin superfamily, member 4
nectin-like protein 3
synaptic cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145977.1 → NP_001139449.1  cell adhesion molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001139449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
    Source sequence(s)
    AK033973, AK043760, AK165030, BB667048, BF458515, CT010571
    Consensus CDS
    CCDS49885.1
    UniProtKB/TrEMBL
    G3UZM4
    Related
    ENSMUSP00000113178.2, ENSMUST00000120898.8
    Conserved Domains (4) summary
    smart00294
    Location:348 → 366
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:240 → 303
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:141 → 223
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:26 → 120
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

  2. NM_001347247.1 → NP_001334176.1  cell adhesion molecule 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and contains an exon in the 3' coding region compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC105980, AC109233, AC154196, AC154428, CJ259603, CT010571
    Consensus CDS
    CCDS84251.1
    UniProtKB/Swiss-Prot
    B1B1A5, B1B1A6, B2RTL0, Q8BLQ9, Q8BXJ7, Q8BYP1, Q8BZP4
    UniProtKB/TrEMBL
    G3UZM4
    Related
    ENSMUSP00000113500.2, ENSMUST00000120594.8
    Conserved Domains (4) summary
    smart00294
    Location:388 → 406
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:240 → 303
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:141 → 223
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:26 → 120
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

  3. NM_178721.4 → NP_848836.2  cell adhesion molecule 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK043760, AK165030, BB667048, BF458515, CT010571
    Consensus CDS
    CCDS28270.1
    UniProtKB/TrEMBL
    G3UZM4
    Related
    ENSMUSP00000109931.2, ENSMUST00000114292.8
    Conserved Domains (5) summary
    smart00294
    Location:357 → 375
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:249 → 312
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:251 → 260
    Ig; Ig strand B [structural motif]
    cd05884
    Location:129 → 232
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:35 → 130
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    66452302..67417825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523026.5 → XP_006523089.1  cell adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    G3UZM4
    Related
    ENSMUSP00000134554.2, ENSMUST00000128168.3
    Conserved Domains (4) summary
    smart00294
    Location:397 → 415
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:249 → 312
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:150 → 232
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:35 → 129
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

  2. XM_011246129.4 → XP_011244431.1  cell adhesion molecule 2 isoform X4

    UniProtKB/TrEMBL
    G3UZM4
    Conserved Domains (5) summary
    smart00294
    Location:371 → 389
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:263 → 326
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:164 → 246
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:49 → 143
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cl29795
    Location:9 → 56
    MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A

  3. XM_011246128.4 → XP_011244430.1  cell adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    G3UZM4
    Conserved Domains (5) summary
    smart00294
    Location:411 → 429
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:263 → 326
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:164 → 246
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:49 → 143
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cl29795
    Location:9 → 56
    MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A

  4. XM_036159925.1 → XP_036015818.1  cell adhesion molecule 2 isoform X6

    Conserved Domains (4) summary
    smart00294
    Location:280 → 298
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:132 → 195
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:134 → 143
    Ig; Ig strand B [structural motif]
    cd05884
    Location:12 → 115
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

  5. XM_036159924.1 → XP_036015817.1  cell adhesion molecule 2 isoform X5

    UniProtKB/TrEMBL
    G3UZM4
    Conserved Domains (5) summary
    smart00294
    Location:353 → 371
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:245 → 308
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:247 → 256
    Ig; Ig strand B [structural motif]
    cd05884
    Location:125 → 228
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:31 → 126
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

  6. XM_036159927.1 → XP_036015820.1  cell adhesion molecule 2 isoform X7

    Conserved Domains (4) summary
    smart00294
    Location:240 → 258
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:132 → 195
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:134 → 143
    Ig; Ig strand B [structural motif]
    cd05884
    Location:12 → 115
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

  7. XM_036159926.1 → XP_036015819.1  cell adhesion molecule 2 isoform X6

    Conserved Domains (4) summary
    smart00294
    Location:280 → 298
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:132 → 195
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:134 → 143
    Ig; Ig strand B [structural motif]
    cd05884
    Location:12 → 115
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

  8. XM_036159923.1 → XP_036015816.1  cell adhesion molecule 2 isoform X3

    UniProtKB/TrEMBL
    G3UZM4
    Conserved Domains (5) summary
    smart00294
    Location:393 → 411
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:245 → 308
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:247 → 256
    Ig; Ig strand B [structural motif]
    cd05884
    Location:125 → 228
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:31 → 126
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

RNA

  1. XR_001781826.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLQ9.2 GenPept UniProtKB/Swiss-Prot:Q8BLQ9

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