Lamp3 lysosomal-associated membrane protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamp3provided by MGI
Official Full Name: lysosomal-associated membrane protein 3provided by MGI
Primary source: MGI:MGI:2441659
See related: Ensembl:ENSMUSG00000041247 AllianceGenome:MGI:2441659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAMP; Cd208; DCLAMP; TSC403; DC-LAMP; 1200002D17Rik
Summary: Predicted to be involved in several processes, including negative regulation of proteolysis; regulation of autophagy; and response to interferon-alpha. Located in alveolar lamellar body membrane and lysosomal membrane. Is expressed in alveolus epithelium; lung; and lung epithelium. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward lung adult (RPKM 35.6) See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 12.17 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (19472131..19525115, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (19653381..19706365, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjogren's Disease.
Title: Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation.
Title: RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation.
Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjogren's disease.
Title: Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.
LAMP3 deficiency affects surfactant homeostasis in mice.
Title: LAMP3 deficiency affects surfactant homeostasis in mice.
LAMP3 is an important regulator of hepatic lipid metabolism.
Title: LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to organelle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in alveolar lamellar body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in alveolar lamellar body membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosome-associated membrane glycoprotein 3

Names: DC LAMP; DC-lysosome-associated membrane glycoprotein; LAMP-3; dendritic cells-lysosome associated membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.