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Dip2b disco interacting protein 2 homolog B [ Mus musculus (house mouse) ]

Gene ID: 239667, updated on 4-Jan-2025

Summary

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Official Symbol
Dip2bprovided by MGI
Official Full Name
disco interacting protein 2 homolog Bprovided by MGI
Primary source
MGI:MGI:2145977
See related
Ensembl:ENSMUSG00000023026 AllianceGenome:MGI:2145977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1463; 4932422C22
Summary
Enables alpha-tubulin binding activity. Involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Located in axon; dendrite; and perikaryon. Is expressed in several structures, including central nervous system; gut; liver; retina; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.4), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dip2b in Genome Data Viewer
Location:
15 F1; 15 56.14 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99935119..100117355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100037626..100219474)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member A Neighboring gene predicted gene, 21917 Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3157 Neighboring gene La ribonucleoprotein 4 Neighboring gene STARR-seq mESC enhancer starr_39735 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99890852-99891153 Neighboring gene STARR-seq mESC enhancer starr_39737 Neighboring gene STARR-seq mESC enhancer starr_39738 Neighboring gene STARR-seq mESC enhancer starr_39739 Neighboring gene STARR-seq mESC enhancer starr_39742 Neighboring gene STARR-seq mESC enhancer starr_39744 Neighboring gene STARR-seq mESC enhancer starr_39745 Neighboring gene activating transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_39746 Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Dip2b leads to abnormal neural differentiation from mESCs. Yao M, et al. Stem Cell Res Ther, 2023 Sep 13. PMID 37705068, Free PMC Article
  2. Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment. Adlat S, et al. Int Immunopharmacol, 2022 Apr. PMID 35091337
  3. Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene. Sah RK, et al. Curr Issues Mol Biol, 2021 Jun 30. PMID 34208944, Free PMC Article
  4. DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth. Xing ZK, et al. Front Cell Neurosci, 2020. PMID 32153366, Free PMC Article
  5. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. Winnepenninckx B, et al. Am J Hum Genet, 2007 Feb. PMID 17236128, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Dip2b leads to abnormal neural differentiation from mESCs.
    Title: Loss of Dip2b leads to abnormal neural differentiation from mESCs.
  2. Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment.
    Title: Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment.
  3. Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene.
    Title: Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene.
  4. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.
    Title: Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1463

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disco-interacting protein 2 homolog B
Names
DIP2 disco-interacting protein 2 homolog B
DIP2 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159361.3 → NP_001152833.1  disco-interacting protein 2 homolog B isoform 1

    See identical proteins and their annotated locations for NP_001152833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124479, AC125526, AC133868
    Consensus CDS
    CCDS49731.1
    UniProtKB/Swiss-Prot
    Q3UH60, Q8C1W5, Q8CDG9, Q8CHA2
    Related
    ENSMUSP00000097777.4, ENSMUST00000100203.10
    Conserved Domains (4) summary
    COG0318
    Location:334 → 910
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:993 → 1468
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:358 → 922
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001402901.1 → NP_001389830.1  disco-interacting protein 2 homolog B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124479, AC125526, AC133868

  3. NM_172819.4 → NP_766407.2  disco-interacting protein 2 homolog B isoform 2

    See identical proteins and their annotated locations for NP_766407.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC124479, AC125526
    Consensus CDS
    CCDS27831.1
    UniProtKB/TrEMBL
    B2RQC7, D3Z5G8
    Related
    ENSMUSP00000023768.8, ENSMUST00000023768.14
    Conserved Domains (3) summary
    COG0318
    Location:100 → 676
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:759 → 1234
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:124 → 688
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99935119..100117355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245629.4 → XP_011243931.1  disco-interacting protein 2 homolog B isoform X1

    Conserved Domains (2) summary
    cd05905
    Location:1050 → 1615
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  2. XM_011245630.4 → XP_011243932.1  disco-interacting protein 2 homolog B isoform X2

    Conserved Domains (2) summary
    cd05905
    Location:1049 → 1614
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  3. XM_011245631.4 → XP_011243933.1  disco-interacting protein 2 homolog B isoform X4

    Conserved Domains (2) summary
    cd05905
    Location:979 → 1544
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  4. XM_011245632.4 → XP_011243934.1  disco-interacting protein 2 homolog B isoform X5

    Conserved Domains (2) summary
    cd05905
    Location:978 → 1543
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UH60.1 GenPept UniProtKB/Swiss-Prot:Q3UH60

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