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Fiz1 Flt3 interacting zinc finger protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23877, updated on 4-Jan-2025

Summary

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Official Symbol
Fiz1provided by MGI
Official Full Name
Flt3 interacting zinc finger protein 1provided by MGI
Primary source
MGI:MGI:1344336
See related
Ensembl:ENSMUSG00000061374 AllianceGenome:MGI:1344336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00416
Summary
Enables receptor tyrosine kinase binding activity. Acts upstream of or within positive regulation of protein phosphorylation. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; sensory organ; and tooth. Orthologous to human FIZ1 (FLT3 interacting zinc finger 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 19.0), ovary adult (RPKM 16.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fiz1 in Genome Data Viewer
Location:
7 A1; 7 2.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5010055..5017727, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5007056..5014728, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 579 Neighboring gene predicted gene, 53351 Neighboring gene STARR-seq mESC enhancer starr_17950 Neighboring gene zinc finger protein 524 Neighboring gene STARR-positive B cell enhancer ABC_E4889 Neighboring gene zinc finger protein 865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells. Yee KW, et al. Blood, 2004 Dec 15. PMID 15304385
  2. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. Mali RS, et al. BMC Mol Biol, 2008 Oct 14. PMID 18854042, Free PMC Article
  3. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Mitton KP, et al. Hum Mol Genet, 2003 Feb 15. PMID 12566383
  4. Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. Wolf I, et al. J Biol Chem, 1999 Jul 23. PMID 10409713
  5. Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. Tsuruyama T, et al. J Leukoc Biol, 2010 Jul. PMID 20360400

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas.
    Title: Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
  2. Fiz1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
    Title: FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
  3. Addition of potent FLT3 inhibitors such as SU11248 to acute myeloid leukemia chemotherapy regimens could result in improved treatment results.
    Title: Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00416, MGC117900

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
flt3-interacting zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110328.2 → NP_001103798.1  flt3-interacting zinc finger protein 1

    See identical proteins and their annotated locations for NP_001103798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AC157563
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Related
    ENSMUSP00000128105.2, ENSMUST00000165320.3
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001110329.1 → NP_001103799.1  flt3-interacting zinc finger protein 1

    See identical proteins and their annotated locations for NP_001103799.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AK142205, AW045450, CJ131593
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Related
    ENSMUSP00000076603.8, ENSMUST00000077385.15
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001110330.1 → NP_001103800.1  flt3-interacting zinc finger protein 1

    See identical proteins and their annotated locations for NP_001103800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AK142205, AW045450, BU053482
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Related
    ENSMUSP00000147011.2, ENSMUST00000208944.2
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001360241.1 → NP_001347170.1  flt3-interacting zinc finger protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. All seven variants encode the same protein.
    Source sequence(s)
    AC157563, BY203086
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001360242.1 → NP_001347171.1  flt3-interacting zinc finger protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AC157563, BC138232
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Related
    ENSMUSP00000147082.2, ENSMUST00000207030.2
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001360243.1 → NP_001347172.1  flt3-interacting zinc finger protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AC157563
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

  7. NM_011813.3 → NP_035943.3  flt3-interacting zinc finger protein 1

    See identical proteins and their annotated locations for NP_035943.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
    Source sequence(s)
    AC157563, AK142205, AW045450
    Consensus CDS
    CCDS20751.1
    UniProtKB/Swiss-Prot
    Q91W14, Q9CTG3, Q9WTJ4
    UniProtKB/TrEMBL
    Q3TRV0, Q571H7
    Related
    ENSMUSP00000126765.2, ENSMUST00000167804.9
    Conserved Domains (2) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:432 → 457
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5010055..5017727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTJ4.1 GenPept UniProtKB/Swiss-Prot:Q9WTJ4

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