Vash1 vasohibin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vash1provided by MGI
Official Full Name: vasohibin 1provided by MGI
Primary source: MGI:MGI:2442543
See related: Ensembl:ENSMUSG00000021256 AllianceGenome:MGI:2442543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TTCP 1; D930046M13Rik; G630009D10Rik
Summary: Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development and negative regulation of angiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 15.3), CNS E14 (RPKM 13.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 40.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (86725474..86742462)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (86678700..86695688)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vasohibin-1 has alpha-tubulin detyrosinating activity in glomerular podocytes.
Title: Vasohibin-1 has α-tubulin detyrosinating activity in glomerular podocytes.
Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice.
Title: Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice.
Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia.
Title: Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia.
VASH1 expression could have protective effects on cisplatin-induced AKI probably by maintaining the number and function of peritubular capillaries.
Title: Renal tubular injury exacerbated by vasohibin-1 deficiency in a murine cisplatin-induced acute kidney injury model.
replicative senescence, the downregulation of VASH1 expression in endothelial cells was caused, at least in part, by the alteration of microRNA expression.
Title: Age-associated downregulation of vasohibin-1 in vascular endothelial cells.
These results indicate that cancer cells proteolytically inactivate VASH1 protein secreted by ECs in the tumour microenvironment
Title: Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells.
Unaffected fibrosis and angiogenesis seen by knocking out endogenous vasohibin-1.
Title: Hepatic fibrosis and angiogenesis after bile duct ligation are endogenously expressed vasohibin-1 independent.
endogenous VASH1 may regulate the development of diabetic renal alterations
Title: Exacerbation of diabetic renal alterations in mice lacking vasohibin-1.
VASH1 and VASH2 showed distinctive localization and opposing function on the fetoplacental vascularization.
Title: Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.
PKCdelta deficiency enhances neointimal formation, which is associated with delayed reendothelialization and involves increased cellular vasohibin-1 accumulation.
Title: Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin-tyrosine carboxypeptidase	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lymphangiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellular senescence	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulinyl-Tyr carboxypeptidase 1

Names: tyrosine carboxypeptidase 1

NP_796328.2

EC 3.4.17.17

XP_011242409.1

EC 3.4.17.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.