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Adam23 a disintegrin and metallopeptidase domain 23 [ Mus musculus (house mouse) ]

Gene ID: 23792, updated on 27-Nov-2024

Summary

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Official Symbol
Adam23provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 23provided by MGI
Primary source
MGI:MGI:1345162
See related
Ensembl:ENSMUSG00000025964 AllianceGenome:MGI:1345162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDC3
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an inactive metalloprotease and disintegrin domains. Transgenic disruption of this gene in mice results in postnatal neurological defects including tremor and ataxia resulting in death by 2 weeks of age. [provided by RefSeq, Sep 2015]
Expression
Broad expression in cerebellum adult (RPKM 24.9), cortex adult (RPKM 15.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Adam23 in Genome Data Viewer
Location:
1 C2; 1 32.31 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63484880..63635263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63445717..63596111)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01139 Neighboring gene STARR-seq mESC enhancer starr_01140 Neighboring gene predicted gene, 35393 Neighboring gene STARR-seq mESC enhancer starr_01141 Neighboring gene predicted gene, 22281 Neighboring gene STARR-seq mESC enhancer starr_01142 Neighboring gene family with sequence similarity 237, member A Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells. Sun Y, et al. Neurochem Res, 2007 Jul. PMID 17333391
  2. ADAM23 is a negative regulator of K(v)1.1/K(v)1.4 potassium currents. Lancaster E, et al. Neurosci Lett, 2019 Jun 21. PMID 30965109
  3. ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling. Xiang M, et al. J Am Heart Assoc, 2018 Sep 18. PMID 30371220, Free PMC Article
  4. Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor. Elizondo DM, et al. J Leukoc Biol, 2016 Nov. PMID 27317750, Free PMC Article
  5. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. Sun YP, et al. Gene, 2004 Jan 21. PMID 14697522

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
    Title: Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
  2. ADAM23 had a strong negative effect on the surface expression of Kv1.1 channels and on Kv1.1 current amplitude
    Title: ADAM23 is a negative regulator of K(v)1.1/K(v)1.4 potassium currents.
  3. we identified ADAM23 as a negative regulator of cardiac hypertrophy through inhibiting focal adhesion kinase-protein kinase B signaling pathway, which could be a promising therapeutic target for this malady
    Title: ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.
  4. ADAM23 expression on DCs partially governs antigen-presentation capacities to responder CD4(+) T cells. Knockdown did not alter the maturation profile of DCs but impaired cognate T cell responses, decreased antigen-specific clonal expansion, and decreased Th cytokine production. Targeting the alpha(v)beta(3) integrin receptors resulted in similar phenotypes indicating their role in the ADAM23 response.
    Title: Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.
  5. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
    Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
  6. Adam23 knockdown up-regulates P27KIP1 in P19/ADAM23 knockdown cells, one reason that P19/ADAM23 knockdown cells can differentiate into neurons without retinoic acid induction.
    Title: ADAM23 knockdown promotes neuronal differentiation of P19 embryonal carcinoma cells by up-regulating P27KIP1 expression.
  7. Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23.
    Title: Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23.
  8. Data suggest that LGI1 binding to ADAM23 is necessary to correctly pattern neuronal morphology, and altered anatomical patterning contributes to autosomal dominant partial epilepsy with auditory features.
    Title: LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.
  9. PrP(C) is a novel molecular partner for ADAM23 in the nervous systems.
    Title: Characterization of a specific interaction between ADAM23 and cellular prion protein.
  10. Functional role of ADAM23 during lung cancer metastatic progression by negatively modulating alpha(v)beta(3) integrin activation.
    Title: ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 23
Names
a disintegrin and metalloprotease domain 23
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011780.3 → NP_035910.1  disintegrin and metalloproteinase domain-containing protein 23 preproprotein

    See identical proteins and their annotated locations for NP_035910.1

    Status: REVIEWED

    Source sequence(s)
    AB009673, AK046677, AL645534, AW046396
    Consensus CDS
    CCDS14999.1
    UniProtKB/Swiss-Prot
    Q6QDY9, Q6QDZ0, Q8CC33, Q9R1V7
    Related
    ENSMUSP00000084633.4, ENSMUST00000087374.10
    Conserved Domains (5) summary
    smart00608
    Location:584 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:296 → 491
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:508 → 581
    Disintegrin; Disintegrin
    pfam01421
    Location:296 → 493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:144 → 246
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63484880..63635263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495969.5 → XP_006496032.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V7
    Related
    ENSMUSP00000109742.2, ENSMUST00000114107.3
    Conserved Domains (4) summary
    smart00608
    Location:584 → 723
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:508 → 580
    Disintegrin
    pfam01421
    Location:296 → 493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:124 → 246
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_006495970.5 → XP_006496033.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q9R1V7
    Related
    ENSMUSP00000139862.2, ENSMUST00000114103.8
    Conserved Domains (4) summary
    smart00608
    Location:584 → 723
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:508 → 580
    Disintegrin
    pfam01421
    Location:296 → 493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:124 → 246
    Pep_M12B_propep; Reprolysin family propeptide

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177600.1: Suppressed sequence

    Description
    NM_001177600.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1V7.1 GenPept UniProtKB/Swiss-Prot:Q9R1V7

Gene LinkOut

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