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CADM1 cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 23705, updated on 27-Nov-2024

Summary

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Official Symbol
CADM1provided by HGNC
Official Full Name
cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:5951
See related
Ensembl:ENSG00000182985 MIM:605686; AllianceGenome:HGNC:5951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1
Summary
Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomarker of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung (RPKM 23.7), thyroid (RPKM 19.5) and 23 other tissues See more
Orthologs
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Genomic context

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See CADM1 in Genome Data Viewer
Location:
11q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (115169236..115504415, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (115182091..115517534, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (115039956..115375133, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene neurexophilin and PC-esterase domain family member 2 Neighboring gene histone deacetylase 2 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:114473708-114474907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3917 Neighboring gene neurexophilin and PC-esterase domain family member 4 Neighboring gene uncharacterized LOC105369506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114717517-114718016 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:114757957-114759156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114800269-114800769 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115035341-115035883 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:115079540-115080739 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:115093260-115094068 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115141547-115142048 Neighboring gene Sharpr-MPRA regulatory region 15022 Neighboring gene uncharacterized LOC105369509 Neighboring gene CADM1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115346934-115347601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3918 Neighboring gene uncharacterized LOC105369511 Neighboring gene ferritin light chain pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TSLC1 gene silencing in cutaneous melanoma. You Y, et al. Melanoma Res, 2010 Jun. PMID 20375924
  2. Hypermethylation of IGSF4 gene for noninvasive prenatal diagnosis of thalassemia. Gao T, et al. Med Sci Monit, 2012 Jan. PMID 22207107, Free PMC Article
  3. Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. Yoneshige A, et al. Respir Res, 2015 Aug 1. PMID 26231557, Free PMC Article
  4. Re-expression of cell adhesion molecule inhibits growth and induces apoptosis of human pancreatic cancer cell line PANC-1. Liu Z, et al. J Huazhong Univ Sci Technolog Med Sci, 2011 Dec. PMID 22173495
  5. Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinoma. Yang G, et al. Int J Gynecol Cancer, 2011 Apr. PMID 21436696

See all (227) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells.
    Title: CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells.
  2. Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study.
    Title: Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study.
  3. Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production.
    Title: Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production.
  4. Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein.
    Title: Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein.
  5. Analysis of the key ligand receptor CADM1_CADM1 in the regulation of thyroid cancer based on scRNA-seq and bulk RNA-seq data.
    Title: Analysis of the key ligand receptor CADM1_CADM1 in the regulation of thyroid cancer based on scRNA-seq and bulk RNA-seq data.
  6. DNA hypermethylation of CADM1, PAX5, WT1, RARbeta, and PAX6 genes in oropharyngeal cancer associated with human papillomavirus.
    Title: DNA hypermethylation of CADM1, PAX5, WT1, RARβ, and PAX6 genes in oropharyngeal cancer associated with human papillomavirus.
  7. Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes.
    Title: Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes.
  8. Knockdown of long non-coding RNA LINC01006 represses the development of hepatocellular carcinoma by modulating the miR-194-5p/CADM1 axis.
    Title: Knockdown of long non-coding RNA LINC01006 represses the development of hepatocellular carcinoma by modulating the miR-194-5p/CADM1 axis.
  9. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.
    Title: The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.
  10. miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1.
    Title: miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1.
Submit: New GeneRIF Correction See all GeneRIFs (182)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC51880, MGC149785, DKFZp686F1789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in activated T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell recognition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in detection of stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERBB4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in susceptibility to natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in susceptibility to natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in susceptibility to natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell adhesion molecule 1
Names
TSLC-1
TSLC1/Nectin-like 2/IGSF4
immunoglobulin superfamily member 4
nectin-like 2
nectin-like protein 2
spermatogenic immunoglobulin superfamily
synaptic cell adhesion molecule
tumor suppressor in lung cancer 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098517.2 → NP_001091987.1  cell adhesion molecule 1 isoform E precursor

    See identical proteins and their annotated locations for NP_001091987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate in-frame exons compared to variant 3. The resulting isoform (2, also known as E) has the same N- and C-termini but is shorter compared to isoform A.
    Source sequence(s)
    AF132811, AP003179, BC125103, BI915307, BM309987, CA447277, CA777709
    Consensus CDS
    CCDS53711.1
    UniProtKB/TrEMBL
    A0A0A0MTJ8
    Related
    ENSP00000439176.1, ENST00000542447.6
    Conserved Domains (3) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00409
    Location:252 → 330
    IG; Immunoglobulin

  2. NM_001301043.2 → NP_001287972.1  cell adhesion molecule 1 isoform A precursor

    See identical proteins and their annotated locations for NP_001287972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AP003179, BC047021, CA447277, HE586498
    Consensus CDS
    CCDS73399.1
    UniProtKB/TrEMBL
    X5D7A8, X5DNF2
    Related
    ENSP00000329797.6, ENST00000331581.11
    Conserved Domains (4) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00408
    Location:259 → 320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252 → 330
    IG_like; Immunoglobulin like

  3. NM_001301044.2 → NP_001287973.1  cell adhesion molecule 1 isoform B precursor

    See identical proteins and their annotated locations for NP_001287973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (B) has the same N- and C-termini but is shorter compared to isoform A.
    Source sequence(s)
    AP003179, BC047021, CA447277, HE586497
    Consensus CDS
    CCDS73398.1
    UniProtKB/TrEMBL
    X5DNF2, X5DQR8
    Related
    ENSP00000439817.1, ENST00000537058.5
    Conserved Domains (4) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00408
    Location:259 → 320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252 → 330
    IG_like; Immunoglobulin like

  4. NM_001301045.2 → NP_001287974.1  cell adhesion molecule 1 isoform C precursor

    See identical proteins and their annotated locations for NP_001287974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (C) has the same N- and C-termini but is shorter compared to isoform A.
    Source sequence(s)
    AP003179, BC047021, CA447277, KJ534797
    Consensus CDS
    CCDS73397.1
    UniProtKB/TrEMBL
    X5DNF2, X5DQS5
    Related
    ENSP00000440322.1, ENST00000536727.5
    Conserved Domains (3) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00409
    Location:252 → 330
    IG; Immunoglobulin

  5. NM_014333.4 → NP_055148.3  cell adhesion molecule 1 isoform D precursor

    See identical proteins and their annotated locations for NP_055148.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (1, also known as D) has the same N- and C-termini but is shorter compared to isoform A.
    Source sequence(s)
    AF132811, AP003179, BC035930, BC125103, BM309987, CA447277, CA777709
    Consensus CDS
    CCDS8373.1
    UniProtKB/Swiss-Prot
    A4FVB5, F5H0J4, H0YGA7, H1ZZV9, H1ZZW1, H1ZZW2, Q86WB8, Q8N2F4, Q9BY67, X5D2C8
    UniProtKB/TrEMBL
    X5D8W0, X5DNF2
    Related
    ENSP00000395359.2, ENST00000452722.7
    Conserved Domains (3) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00409
    Location:252 → 330
    IG; Immunoglobulin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    115169236..115504415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271494.4 → XP_005271551.1  cell adhesion molecule 1 isoform X6

    See identical proteins and their annotated locations for XP_005271551.1

    UniProtKB/TrEMBL
    A0A0A0MTJ8
    Conserved Domains (4) summary
    cd05881
    Location:46 → 140
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    cd05883
    Location:161 → 242
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00408
    Location:259 → 320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252 → 330
    IG_like; Immunoglobulin like

  2. XM_047426695.1 → XP_047282651.1  cell adhesion molecule 1 isoform X8

  3. XM_017017457.3 → XP_016872946.1  cell adhesion molecule 1 isoform X1

    UniProtKB/TrEMBL
    X5DNF2

  4. XM_047426691.1 → XP_047282647.1  cell adhesion molecule 1 isoform X3

  5. XM_047426690.1 → XP_047282646.1  cell adhesion molecule 1 isoform X2

  6. XM_047426693.1 → XP_047282649.1  cell adhesion molecule 1 isoform X5

  7. XM_047426692.1 → XP_047282648.1  cell adhesion molecule 1 isoform X4

  8. XM_047426694.1 → XP_047282650.1  cell adhesion molecule 1 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    115182091..115517534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368269.1 → XP_054224244.1  cell adhesion molecule 1 isoform X6

  2. XM_054368264.1 → XP_054224239.1  cell adhesion molecule 1 isoform X1

  3. XM_054368266.1 → XP_054224241.1  cell adhesion molecule 1 isoform X3

  4. XM_054368265.1 → XP_054224240.1  cell adhesion molecule 1 isoform X2

  5. XM_054368268.1 → XP_054224243.1  cell adhesion molecule 1 isoform X5

  6. XM_054368267.1 → XP_054224242.1  cell adhesion molecule 1 isoform X4

  7. XM_054368270.1 → XP_054224245.1  cell adhesion molecule 1 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BY67.2 GenPept UniProtKB/Swiss-Prot:Q9BY67

Gene LinkOut

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