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Adgrg4 adhesion G protein-coupled receptor G4 [ Mus musculus (house mouse) ]

Gene ID: 236798, updated on 27-Nov-2024

Summary

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Official Symbol
Adgrg4provided by MGI
Official Full Name
adhesion G protein-coupled receptor G4provided by MGI
Primary source
MGI:MGI:2685213
See related
Ensembl:ENSMUSG00000053852 AllianceGenome:MGI:2685213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm367; PGR17; Gpr112
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Adgrg4 in Genome Data Viewer
Location:
X A6; X 30.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55939594..56025719)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56894234..56980359)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene four and a half LIM domains 1 Neighboring gene predicted gene, 23258 Neighboring gene STARR-seq mESC enhancer starr_47209 Neighboring gene MAP7 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_47210 Neighboring gene HIV TAT specific factor 1 Neighboring gene bombesin-like receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
  3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G4
Names
G protein coupled receptor Gpr112
probable G-protein coupled receptor 112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362885.1 → NP_001349814.1  adhesion G-protein coupled receptor G4

    Status: VALIDATED

    Source sequence(s)
    AL671998, AL672263
    UniProtKB/Swiss-Prot
    B7ZCC9, B7ZCD0
    Related
    ENSMUSP00000116634.2, ENSMUST00000153784.8
    Conserved Domains (4) summary
    pfam01825
    Location:2587 → 2629
    GPS; GPCR proteolysis site, GPS, motif
    cd15997
    Location:2642 → 2903
    7tmB2_GPR112; Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl22861
    Location:54 → 162
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28246
    Location:276 → 746
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    55939594..56025719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033327.2: Suppressed sequence

    Description
    NM_001033327.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001110790.1: Suppressed sequence

    Description
    NM_001110790.1: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7ZCC9.1 GenPept UniProtKB/Swiss-Prot:B7ZCC9

Gene LinkOut

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