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Dhrsx dehydrogenase/reductase X linked [ Mus musculus (house mouse) ]

Gene ID: 236082, updated on 27-Nov-2024

Summary

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Official Symbol
Dhrsxprovided by MGI
Official Full Name
dehydrogenase/reductase X linkedprovided by MGI
Primary source
MGI:MGI:2181510
See related
AllianceGenome:MGI:2181510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pscad; Dhrsxy; D4Ertd296e
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in positive regulation of autophagy. Predicted to be located in lipid droplet. Predicted to be active in extracellular region. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Dhrsx in Genome Data Viewer
Location:
4 E2; 4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156390105..156410432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 Unlocalized Scaffold NT_166291.1 (14351..36213)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 11 Neighboring gene predicted gene, 47252 Neighboring gene predicted gene, 54274 Neighboring gene predicted gene, 53226 Neighboring gene predicted gene, 54275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. Gianfrancesco F, et al. Genome Res, 2001 Dec. PMID 11731500, Free PMC Article
  2. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC170222, MGC170224

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichal reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables polyprenol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dolichol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
polyprenol dehydrogenase; dehydrogenase/reductase SDR family member on chromosome X homolog
Names
SCAD family protein
dehydrogenase/reductase (SDR family) X chromosome
dehydrogenase/reductase SDR family member on chromosome Y
dolichal reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033326.3 → NP_001028498.2  polyprenol dehydrogenase isoform 1

    Status: VALIDATED

    Source sequence(s)
    CAAA01118383, CAAA01125276
    UniProtKB/Swiss-Prot
    B2RRV9, Q3TZW6, Q8VBZ0
    Conserved Domains (2) summary
    cd05327
    Location:43 → 316
    retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
    PRK06197
    Location:38 → 324
    PRK06197; short chain dehydrogenase; Provisional

  2. NM_001368261.1 → NP_001355190.1  polyprenol dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CAAA01118383, CAAA01125276
    UniProtKB/Swiss-Prot
    B2RRV9, Q3TZW6, Q8VBZ0

  3. NM_001368262.1 → NP_001355191.1  polyprenol dehydrogenase isoform 3

    Status: VALIDATED

    Source sequence(s)
    CAAA01118383, CAAA01125276
    UniProtKB/Swiss-Prot
    B2RRV9, Q3TZW6, Q8VBZ0

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156390105..156410432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251639.2 → XP_030107499.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1 → 184
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_030251637.2 → XP_030107497.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:1 → 226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_030251638.2 → XP_030107498.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:6 → 192
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_006535904.5 → XP_006535967.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1 → 184
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_006535901.4 → XP_006535964.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:37 → 246
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VBZ0.2 GenPept UniProtKB/Swiss-Prot:Q8VBZ0

Gene LinkOut

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