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Plscr4 phospholipid scramblase 4 [ Mus musculus (house mouse) ]

Gene ID: 235527, updated on 27-Nov-2024

Summary

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Official Symbol
Plscr4provided by MGI
Official Full Name
phospholipid scramblase 4provided by MGI
Primary source
MGI:MGI:2143267
See related
Ensembl:ENSMUSG00000032377 AllianceGenome:MGI:2143267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable CD4 receptor binding activity; enzyme binding activity; and phospholipid scramblase activity. Involved in cellular response to lipopolysaccharide. Predicted to be active in plasma membrane. Is expressed in esophagus. Orthologous to human PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 12.3), lung adult (RPKM 8.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Plscr4 in Genome Data Viewer
Location:
9 E3.3; 9 48.39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92339431..92374509)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92457372..92493513)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 2 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene STARR-seq mESC enhancer starr_24898 Neighboring gene predicted gene 15493 Neighboring gene STARR-seq mESC enhancer starr_24899 Neighboring gene RIKEN cDNA B430319G15 gene Neighboring gene predicted gene, 25417 Neighboring gene procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phospholipid scramblase expression in the pregnant mouse uterus in LPS-induced preterm delivery. McLean KC, et al. Reprod Sci, 2012 Nov. PMID 22598484, Free PMC Article
  2. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Lu B, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590392
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid scramblase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid scramblase 4
Names
PL scramblase 4
ca(2+)-dependent phospholipid scramblase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410496.1 → NP_001397425.1  phospholipid scramblase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009720

  2. NM_178711.4 → NP_848826.1  phospholipid scramblase 4 isoform 1

    See identical proteins and their annotated locations for NP_848826.1

    Status: VALIDATED

    Source sequence(s)
    CT009720
    Consensus CDS
    CCDS23407.1
    UniProtKB/Swiss-Prot
    P58196, Q3TMI2, Q8BH62
    UniProtKB/TrEMBL
    Q8BW59
    Related
    ENSMUSP00000034941.8, ENSMUST00000034941.9
    Conserved Domains (2) summary
    pfam03803
    Location:96 → 318
    Scramblase; Scramblase
    pfam11029
    Location:27 → 113
    DAZAP2; DAZ associated protein 2 (DAZAP2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    92339431..92374509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58196.2 GenPept UniProtKB/Swiss-Prot:P58196

Gene LinkOut

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