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Nfrkb nuclear factor related to kappa B binding protein [ Mus musculus (house mouse) ]

Gene ID: 235134, updated on 13-Jan-2025

Summary

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Official Symbol
Nfrkbprovided by MGI
Official Full Name
nuclear factor related to kappa B binding proteinprovided by MGI
Primary source
MGI:MGI:2442410
See related
Ensembl:ENSMUSG00000042185 AllianceGenome:MGI:2442410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A530090G11Rik
Summary
Predicted to enable protease binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NFRKB (nuclear factor related to kappaB binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 21.3), spleen adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nfrkb in Genome Data Viewer
Location:
9 A4; 9 16.86 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31297476..31332629)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31386162..31421333)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23695 Neighboring gene PR domain containing 10 Neighboring gene predicted gene 10910 Neighboring gene STARR-seq mESC enhancer starr_23697 Neighboring gene STARR-seq mESC enhancer starr_23701 Neighboring gene RIKEN cDNA 1700023A20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9326 Neighboring gene STARR-positive B cell enhancer ABC_E8852 Neighboring gene STARR-seq mESC enhancer starr_23704 Neighboring gene STARR-seq mESC enhancer starr_23705 Neighboring gene transmembrane protein 45b Neighboring gene STARR-seq mESC enhancer starr_23707 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23708 Neighboring gene STARR-seq mESC enhancer starr_23709 Neighboring gene predicted gene, 31408 Neighboring gene dihydrofolate reductase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
  2. Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Nakaya N, et al. Exp Neurol, 2013 Dec. PMID 24095980, Free PMC Article
  3. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear factor related to kappa-B-binding protein
Names
DNA-binding protein R kappa-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359654.2 → NP_001346583.1  nuclear factor related to kappa-B-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167244
    Conserved Domains (3) summary
    pfam14465
    Location:149 → 233
    NFRKB_winged; NFRKB Winged Helix-like
    cl26464
    Location:489 → 660
    Atrophin-1; Atrophin-1 family
    cl27894
    Location:614 → 944
    DUF1522; Domain of Unknown Function (DUF1522)

  2. NM_001405097.1 → NP_001392026.1  nuclear factor related to kappa-B-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167244

  3. NM_001405098.1 → NP_001392027.1  nuclear factor related to kappa-B-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC167244

  4. NM_001405099.1 → NP_001392028.1  nuclear factor related to kappa-B-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC167244

  5. NM_001405101.1 → NP_001392030.1  nuclear factor related to kappa-B-binding protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC167244

  6. NM_001405102.1 → NP_001392031.1  nuclear factor related to kappa-B-binding protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC167244

  7. NM_172766.4 → NP_766354.2  nuclear factor related to kappa-B-binding protein isoform 1

    See identical proteins and their annotated locations for NP_766354.2

    Status: VALIDATED

    Source sequence(s)
    AC167244
    Consensus CDS
    CCDS22949.1
    UniProtKB/Swiss-Prot
    Q6PIJ4, Q8BWV5, Q8K0X6
    Related
    ENSMUSP00000083341.6, ENSMUST00000086167.12
    Conserved Domains (1) summary
    pfam14465
    Location:392 → 476
    NFRKB_winged; NFRKB Winged Helix-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31297476..31332629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313307.3 → XP_017168796.1  nuclear factor related to kappa-B-binding protein isoform X4

    Conserved Domains (3) summary
    PRK12688
    Location:823 → 1153
    PRK12688; flagellin; Reviewed
    PHA03247
    Location:698 → 869
    PHA03247; large tegument protein UL36; Provisional
    pfam14465
    Location:358 → 444
    NFRKB_winged; NFRKB Winged Helix-like

  2. XM_017313308.3 → XP_017168797.1  nuclear factor related to kappa-B-binding protein isoform X5

    Conserved Domains (3) summary
    PRK12688
    Location:822 → 1152
    PRK12688; flagellin; Reviewed
    PHA03247
    Location:697 → 868
    PHA03247; large tegument protein UL36; Provisional
    pfam14465
    Location:358 → 444
    NFRKB_winged; NFRKB Winged Helix-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PIJ4.1 GenPept UniProtKB/Swiss-Prot:Q6PIJ4

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